Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non‐small cell lung cancer cells via Nrf2 inhibition

Background and Purpose Non‐small‐cell lung cancer (NSCLC) accounts for up to 80–85% of all lung cancers and has a disappointing prognosis. Flavonoids exert anticancer properties, mostly involving stimulation of ROS production without significant toxicity to normal cells. This study was aimed to deli...

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Veröffentlicht in:	British journal of pharmacology 2019-06, Vol.176 (12), p.2079-2094
Hauptverfasser:	Chen, Xiangcui, Wu, Qipeng, Chen, Yueming, Zhang, Jiahao, Li, Huachao, Yang, Zhicheng, Yang, Yang, Deng, Yanchao, Zhang, Luyong, Liu, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Flavonoids - chemistry Flavonoids - pharmacology Humans Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Molecular Structure NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - metabolism Paclitaxel - chemistry Paclitaxel - pharmacology Reactive Oxygen Species - analysis Reactive Oxygen Species - metabolism Research Paper Research Papers Structure-Activity Relationship
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