Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes

Dual specificity phosphatase 6 (DUSP6) is a protein phosphatase that deactivates extracellular-signal-regulated kinase (ERK). Since the ovarian cancer biomarker human epididymis protein 4 (HE4) interacts with the ERK pathway, we sought to determine the relationship between DUSP6 and HE4 and elucidat...

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Veröffentlicht in:	Oncotarget 2019-05, Vol.10 (36), p.3315-3327
Hauptverfasser:	James, Nicole E, Beffa, Lindsey, Oliver, Matthew T, Borgstadt, Ashley D, Emerson, Jenna B, Chichester, Clinton O, Yano, Naohiro, Freiman, Richard N, DiSilvestro, Paul A, Ribeiro, Jennifer R
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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