Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients
To determine the prevalence of chronic kidney disease (CKD) and the epidemiological, clinical, and laboratory factors associated with CKD in Mexican HIV-infected patients. Cross-sectional study. We included 274 patients with HIV/AIDS. CKD was defined by the estimated glomerular filtration rate (eGFR...
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| Veröffentlicht in: | Brazilian Journal of Nephrology 2019-03, Vol.41 (1), p.48-54 |
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| creator | Lopez, Edgar Dehesa Córdova-Cázarez, Carlos Valdez-Ortiz, Rafael Cardona-Landeros, Carlie Michelle Gutiérrez-Rico, María Fernanda |
| description | To determine the prevalence of chronic kidney disease (CKD) and the epidemiological, clinical, and laboratory factors associated with CKD in Mexican HIV-infected patients.
Cross-sectional study. We included 274 patients with HIV/AIDS. CKD was defined by the estimated glomerular filtration rate (eGFR < 60 mL/min/1.73 m2 assessed by CKD-EPI) and albuminuria criteria from KDIGO guidelines. Clinical, epidemiological, and laboratory characteristics were compared between patients with and without CKD. The factors associated with CKD were assessed by logistic regression analysis.
The mean age was 41±11 years, and 72.3% of the patients were men. The global prevalence of CKD was 11.7% (n = 32); 7.2% (n = 20) were defined by eGFR criterion; 7.6% (n = 21), by the albuminuria criterion; and 3.2% (n = 9), by both CKD criteria. The most frequently observed stages of CKD were KDIGO G3A1 stage with 4.7% (n = 13), KDIGO G1A2 stage with 3.6% (n = 10) and KDIGO G3A2 stage with 1.7% (n = 5). The factors associated with CKD were use of abacavir/lamivudine (OR 3.2; 95% CI 1.1-8.9; p = 0.03), a CD4 lymphocyte count < 400 cells/µL (OR 2.6; 95% 1.03-6.4, p = 0.04), age (OR 1.1; 95% CI 1.04-1.2, p = 0.001) and albuminuria (OR 19.98; 95% CI: 5.5-72.2; p < 0.001).
CKD was a frequent complication in HIV-infected patients. These findings confirm the importance of screening and the early detection of CKD, as well as the importance of identifying and treating traditional and non-traditional risk factors associated with CKD. |
| doi_str_mv | 10.1590/2175-8239-JBN-2018-0024 |
| format | Article |
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Cross-sectional study. We included 274 patients with HIV/AIDS. CKD was defined by the estimated glomerular filtration rate (eGFR < 60 mL/min/1.73 m2 assessed by CKD-EPI) and albuminuria criteria from KDIGO guidelines. Clinical, epidemiological, and laboratory characteristics were compared between patients with and without CKD. The factors associated with CKD were assessed by logistic regression analysis.
The mean age was 41±11 years, and 72.3% of the patients were men. The global prevalence of CKD was 11.7% (n = 32); 7.2% (n = 20) were defined by eGFR criterion; 7.6% (n = 21), by the albuminuria criterion; and 3.2% (n = 9), by both CKD criteria. The most frequently observed stages of CKD were KDIGO G3A1 stage with 4.7% (n = 13), KDIGO G1A2 stage with 3.6% (n = 10) and KDIGO G3A2 stage with 1.7% (n = 5). The factors associated with CKD were use of abacavir/lamivudine (OR 3.2; 95% CI 1.1-8.9; p = 0.03), a CD4 lymphocyte count < 400 cells/µL (OR 2.6; 95% 1.03-6.4, p = 0.04), age (OR 1.1; 95% CI 1.04-1.2, p = 0.001) and albuminuria (OR 19.98; 95% CI: 5.5-72.2; p < 0.001).
CKD was a frequent complication in HIV-infected patients. These findings confirm the importance of screening and the early detection of CKD, as well as the importance of identifying and treating traditional and non-traditional risk factors associated with CKD.</description><identifier>ISSN: 0101-2800</identifier><identifier>ISSN: 2175-8239</identifier><identifier>EISSN: 2175-8239</identifier><identifier>DOI: 10.1590/2175-8239-JBN-2018-0024</identifier><identifier>PMID: 30010693</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Nefrologia</publisher><subject>Adult ; Age Factors ; Albuminuria ; Anti-HIV Agents - adverse effects ; CD4 Lymphocyte Count ; Cross-Sectional Studies ; Diabetes Complications ; Dideoxynucleosides - adverse effects ; Female ; Glomerular Filtration Rate ; HIV ; HIV Infections - complications ; Humans ; Hypertension - complications ; Lamivudine - adverse effects ; Logistic Models ; Male ; Mexico - epidemiology ; Middle Aged ; Original ; Prevalence ; Renal Insufficiency ; Renal Insufficiency, Chronic ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - etiology ; Retrospective Studies ; Risk Factors</subject><ispartof>Brazilian Journal of Nephrology, 2019-03, Vol.41 (1), p.48-54</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4374-94c63cea1af5d83901064ac722c00fe754051417d0206a503aa262bb1179fb1b3</citedby><cites>FETCH-LOGICAL-c4374-94c63cea1af5d83901064ac722c00fe754051417d0206a503aa262bb1179fb1b3</cites><orcidid>0000-0001-8239-061X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534026/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534026/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30010693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopez, Edgar Dehesa</creatorcontrib><creatorcontrib>Córdova-Cázarez, Carlos</creatorcontrib><creatorcontrib>Valdez-Ortiz, Rafael</creatorcontrib><creatorcontrib>Cardona-Landeros, Carlie Michelle</creatorcontrib><creatorcontrib>Gutiérrez-Rico, María Fernanda</creatorcontrib><title>Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients</title><title>Brazilian Journal of Nephrology</title><addtitle>J Bras Nefrol</addtitle><description>To determine the prevalence of chronic kidney disease (CKD) and the epidemiological, clinical, and laboratory factors associated with CKD in Mexican HIV-infected patients.
Cross-sectional study. We included 274 patients with HIV/AIDS. CKD was defined by the estimated glomerular filtration rate (eGFR < 60 mL/min/1.73 m2 assessed by CKD-EPI) and albuminuria criteria from KDIGO guidelines. Clinical, epidemiological, and laboratory characteristics were compared between patients with and without CKD. The factors associated with CKD were assessed by logistic regression analysis.
The mean age was 41±11 years, and 72.3% of the patients were men. The global prevalence of CKD was 11.7% (n = 32); 7.2% (n = 20) were defined by eGFR criterion; 7.6% (n = 21), by the albuminuria criterion; and 3.2% (n = 9), by both CKD criteria. The most frequently observed stages of CKD were KDIGO G3A1 stage with 4.7% (n = 13), KDIGO G1A2 stage with 3.6% (n = 10) and KDIGO G3A2 stage with 1.7% (n = 5). The factors associated with CKD were use of abacavir/lamivudine (OR 3.2; 95% CI 1.1-8.9; p = 0.03), a CD4 lymphocyte count < 400 cells/µL (OR 2.6; 95% 1.03-6.4, p = 0.04), age (OR 1.1; 95% CI 1.04-1.2, p = 0.001) and albuminuria (OR 19.98; 95% CI: 5.5-72.2; p < 0.001).
CKD was a frequent complication in HIV-infected patients. These findings confirm the importance of screening and the early detection of CKD, as well as the importance of identifying and treating traditional and non-traditional risk factors associated with CKD.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Albuminuria</subject><subject>Anti-HIV Agents - adverse effects</subject><subject>CD4 Lymphocyte Count</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Complications</subject><subject>Dideoxynucleosides - adverse effects</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Lamivudine - adverse effects</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Mexico - epidemiology</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Prevalence</subject><subject>Renal Insufficiency</subject><subject>Renal Insufficiency, Chronic</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - etiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0101-2800</issn><issn>2175-8239</issn><issn>2175-8239</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpVkV1vFCEUhonR2E3tX1B-gNTDxwzDjYk21a6peqPekjPA7FJnYQOjdv-9M65u7NUhvHkfDnkIecHhkjcGXgmuG9YJadiHt5-YAN4xAKEekdUpeUxWwIEz0QGckYtaYw8SuFG6k0_JmYQ5bY1ckcP1Pvqwi3nMm-hwfEndGNPxhMnTEftccMrlQAd086wUa80u4hQ8_RWnLXXbkucG_R59CgfqYw1YA42Jfgz3MynRm_U3FtMQ3NLZ4xRDmuoz8mTAsYaLv_OcfH13_eXqht1-fr--enPLnJJaMaNcK11AjkPjO2mWxRU6LYQDGIJuFDRcce1BQIsNSETRir7nXJuh5708J-sj12e8s_sSd1gONmO0fy5y2VgsU3RjsIGjAq-5Cl2rlOMoTSM6gSYYdK7VM-v1kbX_0e-Cd_M_Co4PoA-TFLd2k3_atpEKRDsD9BHgSq61hOHU5WAXuXZRaBeF9q5PdpFrF7lz8_n_T596_1TK35xgolc</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Lopez, Edgar Dehesa</creator><creator>Córdova-Cázarez, Carlos</creator><creator>Valdez-Ortiz, Rafael</creator><creator>Cardona-Landeros, Carlie Michelle</creator><creator>Gutiérrez-Rico, María Fernanda</creator><general>Sociedade Brasileira de Nefrologia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8239-061X</orcidid></search><sort><creationdate>20190301</creationdate><title>Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients</title><author>Lopez, Edgar Dehesa ; Córdova-Cázarez, Carlos ; Valdez-Ortiz, Rafael ; Cardona-Landeros, Carlie Michelle ; Gutiérrez-Rico, María Fernanda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4374-94c63cea1af5d83901064ac722c00fe754051417d0206a503aa262bb1179fb1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Albuminuria</topic><topic>Anti-HIV Agents - adverse effects</topic><topic>CD4 Lymphocyte Count</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Complications</topic><topic>Dideoxynucleosides - adverse effects</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Lamivudine - adverse effects</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Mexico - epidemiology</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Prevalence</topic><topic>Renal Insufficiency</topic><topic>Renal Insufficiency, Chronic</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Renal Insufficiency, Chronic - etiology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopez, Edgar Dehesa</creatorcontrib><creatorcontrib>Córdova-Cázarez, Carlos</creatorcontrib><creatorcontrib>Valdez-Ortiz, Rafael</creatorcontrib><creatorcontrib>Cardona-Landeros, Carlie Michelle</creatorcontrib><creatorcontrib>Gutiérrez-Rico, María Fernanda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Brazilian Journal of Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopez, Edgar Dehesa</au><au>Córdova-Cázarez, Carlos</au><au>Valdez-Ortiz, Rafael</au><au>Cardona-Landeros, Carlie Michelle</au><au>Gutiérrez-Rico, María Fernanda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients</atitle><jtitle>Brazilian Journal of Nephrology</jtitle><addtitle>J Bras Nefrol</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>41</volume><issue>1</issue><spage>48</spage><epage>54</epage><pages>48-54</pages><issn>0101-2800</issn><issn>2175-8239</issn><eissn>2175-8239</eissn><abstract>To determine the prevalence of chronic kidney disease (CKD) and the epidemiological, clinical, and laboratory factors associated with CKD in Mexican HIV-infected patients.
Cross-sectional study. We included 274 patients with HIV/AIDS. CKD was defined by the estimated glomerular filtration rate (eGFR < 60 mL/min/1.73 m2 assessed by CKD-EPI) and albuminuria criteria from KDIGO guidelines. Clinical, epidemiological, and laboratory characteristics were compared between patients with and without CKD. The factors associated with CKD were assessed by logistic regression analysis.
The mean age was 41±11 years, and 72.3% of the patients were men. The global prevalence of CKD was 11.7% (n = 32); 7.2% (n = 20) were defined by eGFR criterion; 7.6% (n = 21), by the albuminuria criterion; and 3.2% (n = 9), by both CKD criteria. The most frequently observed stages of CKD were KDIGO G3A1 stage with 4.7% (n = 13), KDIGO G1A2 stage with 3.6% (n = 10) and KDIGO G3A2 stage with 1.7% (n = 5). The factors associated with CKD were use of abacavir/lamivudine (OR 3.2; 95% CI 1.1-8.9; p = 0.03), a CD4 lymphocyte count < 400 cells/µL (OR 2.6; 95% 1.03-6.4, p = 0.04), age (OR 1.1; 95% CI 1.04-1.2, p = 0.001) and albuminuria (OR 19.98; 95% CI: 5.5-72.2; p < 0.001).
CKD was a frequent complication in HIV-infected patients. These findings confirm the importance of screening and the early detection of CKD, as well as the importance of identifying and treating traditional and non-traditional risk factors associated with CKD.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Nefrologia</pub><pmid>30010693</pmid><doi>10.1590/2175-8239-JBN-2018-0024</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8239-061X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Albuminuria Anti-HIV Agents - adverse effects CD4 Lymphocyte Count Cross-Sectional Studies Diabetes Complications Dideoxynucleosides - adverse effects Female Glomerular Filtration Rate HIV HIV Infections - complications Humans Hypertension - complications Lamivudine - adverse effects Logistic Models Male Mexico - epidemiology Middle Aged Original Prevalence Renal Insufficiency Renal Insufficiency, Chronic Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - etiology Retrospective Studies Risk Factors |
| title | Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients |
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