Sildenafil Reduces Neointimal Hyperplasia after Angioplasty and Inhibits Platelet Aggregation via Activation of cGMP-dependent Protein Kinase

Sildenafil is known to reduce cardiac hypertrophy through cGMP-dependent protein kinase (cGK) activation. Studies have demonstrated that cGK has a central switching role in modulating vascular smooth muscle cell (VSMC) phenotype in response to vascular injury. Here, we aimed to examine the effects o...

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Veröffentlicht in:	Scientific reports 2019-05, Vol.9 (1), p.7769-7769, Article 7769
Hauptverfasser:	Yang, Han-Mo, Jin, Sooryeonhwa, Jang, Hyunduk, Kim, Ju-Young, Lee, Joo-Eun, Kim, Joonoh, Kim, Hyo-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	13 42 42/109 631/80/304 64 692/4019/592/75/593/2728 Angioplasty Animals Blood platelets Carotid artery Cell Movement - drug effects Cell Proliferation - drug effects Cyclic GMP Cyclic GMP-Dependent Protein Kinases - metabolism Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism Drug delivery Gene transfer Humanities and Social Sciences Hyperplasia Hypertrophy Implants Kinases multidisciplinary Muscle contraction Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Neointima - metabolism Phenotypes Platelet aggregation Platelet Aggregation - drug effects Platelet-derived growth factor Protein kinase Protein kinase G Rats Restenosis Science Science (multidisciplinary) Signal Transduction - drug effects Sildenafil Sildenafil Citrate - pharmacology Smooth muscle Stents Thrombin Thromboembolism Thrombosis Vascular System Injuries - metabolism
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