Mechanisms of CD8+ T cell‐mediated suppression of HIV/SIV replication

In this article, we summarize the role of CD8+ T cells during natural and antiretroviral therapy (ART)‐treated HIV and SIV infections, discuss the mechanisms responsible for their suppressive activity, and review the rationale for CD8+ T cell‐based HIV cure strategies. Evidence suggests that CD8+ T ...

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Veröffentlicht in:	European journal of immunology 2018-06, Vol.48 (6), p.898-914
Hauptverfasser:	McBrien, Julia Bergild, Kumar, Nitasha A., Silvestri, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Retroviral Agents - therapeutic use Antiretroviral agents Antiretroviral therapy CD8 antigen CD8 T cells CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Cytolytic activity Cytotoxicity Cytotoxicity, Immunologic Gene Expression Regulation, Viral HIV HIV - physiology HIV Infections - drug therapy HIV Infections - immunology Human immunodeficiency virus Humans Immune response Infections Infectious disease Latent infection Lymphocytes Lymphocytes T Macaca mulatta Replication Simian Acquired Immunodeficiency Syndrome - drug therapy Simian Acquired Immunodeficiency Syndrome - immunology Simian Immunodeficiency Virus - physiology Transcription Viral Load Viremia Virus Latency Virus Replication - immunology
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