Correlation of the endoscopic findings for small and large bowels in pediatric patients with established Crohn’s disease
Small bowel capsule endoscopy can detect subtle mucosal lesions in pediatric patients with Crohn’s disease, and our aim was to evaluate its application in established ileocolonic Crohn’s disease. Colonic inflammation was evaluated with the colonic Simple Endoscopic Score for Crohn’s Disease (SES-CD)...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 2019, Vol.64(3), pp.257-264 |
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| container_title | Journal of Clinical Biochemistry and Nutrition |
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| creator | Okuhira, Takeru Yoden, Atsushi Aomatsu, Tomoki Akamatsu, Masano Inoue, Keisuke Kaji, Emiri Takitani, Kimitaka Tamai, Hiroshi |
| description | Small bowel capsule endoscopy can detect subtle mucosal lesions in pediatric patients with Crohn’s disease, and our aim was to evaluate its application in established ileocolonic Crohn’s disease. Colonic inflammation was evaluated with the colonic Simple Endoscopic Score for Crohn’s Disease (SES-CD) (excluding the score of the terminal ileum). Small bowel inflammation was evaluated with the Lewis score and/or Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI). A Lewis score |
| doi_str_mv | 10.3164/jcbn.18-83 |
| format | Article |
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Colonic inflammation was evaluated with the colonic Simple Endoscopic Score for Crohn’s Disease (SES-CD) (excluding the score of the terminal ileum). Small bowel inflammation was evaluated with the Lewis score and/or Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI). A Lewis score <135 was defined as small bowel inactive. A colonic SES-CD of 0 (colonic inactive group) was observed in 22/42 procedures (52.4%), and active small bowel lesions were observed in 11/22 procedures (50.0%). The Lewis score was lower in the colonic inactive group compared to the colonic active group. Correlations between the colonic SES-CD, the Lewis score and CECDAI were weak. The Lewis score and CECDAI in the colonic inactive group had significant correlation with fecal calprotectin levels. We suggest that Crohn’s disease patients without both colonic active lesions and elevation of fecal calprotectin levels may not need to receive small bowel capsule endoscopy due to low incidence of lesions in small bowel.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.18-83</identifier><identifier>PMID: 31138961</identifier><language>eng</language><publisher>Japan: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>capsule endoscopy ; Colon ; Endoscopy ; fecal calprotectin ; Ileum ; Lesions ; Lewis score ; Mucosa ; Original ; pediatric Crohn’s disease ; Pediatrics ; Small intestine</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 2019, Vol.64(3), pp.257-264</ispartof><rights>2019 JCBN</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><rights>Copyright © 2019 JCBN Copyright © 2019 JCBN 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-73001f2e258ed0e23d400637ebf54cffdfff069cb661b2dc7703fd007cfa70053</citedby><cites>FETCH-LOGICAL-c483t-73001f2e258ed0e23d400637ebf54cffdfff069cb661b2dc7703fd007cfa70053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529702/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529702/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,1884,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31138961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okuhira, Takeru</creatorcontrib><creatorcontrib>Yoden, Atsushi</creatorcontrib><creatorcontrib>Aomatsu, Tomoki</creatorcontrib><creatorcontrib>Akamatsu, Masano</creatorcontrib><creatorcontrib>Inoue, Keisuke</creatorcontrib><creatorcontrib>Kaji, Emiri</creatorcontrib><creatorcontrib>Takitani, Kimitaka</creatorcontrib><creatorcontrib>Tamai, Hiroshi</creatorcontrib><title>Correlation of the endoscopic findings for small and large bowels in pediatric patients with established Crohn’s disease</title><title>Journal of Clinical Biochemistry and Nutrition</title><addtitle>J. Clin. Biochem. Nutr.</addtitle><description>Small bowel capsule endoscopy can detect subtle mucosal lesions in pediatric patients with Crohn’s disease, and our aim was to evaluate its application in established ileocolonic Crohn’s disease. Colonic inflammation was evaluated with the colonic Simple Endoscopic Score for Crohn’s Disease (SES-CD) (excluding the score of the terminal ileum). Small bowel inflammation was evaluated with the Lewis score and/or Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI). A Lewis score <135 was defined as small bowel inactive. A colonic SES-CD of 0 (colonic inactive group) was observed in 22/42 procedures (52.4%), and active small bowel lesions were observed in 11/22 procedures (50.0%). The Lewis score was lower in the colonic inactive group compared to the colonic active group. Correlations between the colonic SES-CD, the Lewis score and CECDAI were weak. The Lewis score and CECDAI in the colonic inactive group had significant correlation with fecal calprotectin levels. We suggest that Crohn’s disease patients without both colonic active lesions and elevation of fecal calprotectin levels may not need to receive small bowel capsule endoscopy due to low incidence of lesions in small bowel.</description><subject>capsule endoscopy</subject><subject>Colon</subject><subject>Endoscopy</subject><subject>fecal calprotectin</subject><subject>Ileum</subject><subject>Lesions</subject><subject>Lewis score</subject><subject>Mucosa</subject><subject>Original</subject><subject>pediatric Crohn’s disease</subject><subject>Pediatrics</subject><subject>Small intestine</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkc2KFDEURgtRnHZ04wNIwI0INd5UqlKpjSiNfzDgRtchldx0pUknZVI9g7Oa1_D1fBLT9tiom2RxTw7fzVdVTylcMMrbV1s9hgsqasHuVSsqBNQdCH6_WsFAmxoAhrPqUc5bgJZ3vH1YnTFKmRg4XVU365gSerW4GEi0ZJmQYDAx6zg7TawLxoVNJjYmknfKe6KCIV6lDZIxXqPPxAUyo3FqSeXBXEwYlkyu3TIRzIsavcsTGrJOcQo_b39kYlxGlfFx9cAqn_HJ3X1efX3_7sv6Y335-cOn9dvLWreCLXXPAKhtsOkEGsCGmRaAsx5H27XaWmOtBT7okXM6Nkb3PTBrAHptVQ_QsfPq9dE778cdGl3iJeXlnNxOpe8yKif_nQQ3yU28krxrhh6aInhxJ0jx277sJHcua_ReBYz7LJuGUdG1XBzQ5_-h27hPoaxXqJY2HCjlhXp5pHSKOSe0pzAU5KFSeahUUiEFK_Czv-Of0D8dFuDNEdiW397gCVBpcdrj0VWc7HD8dp5GelJJYmC_APlrt-k</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Okuhira, Takeru</creator><creator>Yoden, Atsushi</creator><creator>Aomatsu, Tomoki</creator><creator>Akamatsu, Masano</creator><creator>Inoue, Keisuke</creator><creator>Kaji, Emiri</creator><creator>Takitani, Kimitaka</creator><creator>Tamai, Hiroshi</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Japan Science and Technology Agency</general><general>the Society for Free Radical Research Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190501</creationdate><title>Correlation of the endoscopic findings for small and large bowels in pediatric patients with established Crohn’s disease</title><author>Okuhira, Takeru ; Yoden, Atsushi ; Aomatsu, Tomoki ; Akamatsu, Masano ; Inoue, Keisuke ; Kaji, Emiri ; Takitani, Kimitaka ; Tamai, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-73001f2e258ed0e23d400637ebf54cffdfff069cb661b2dc7703fd007cfa70053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>capsule endoscopy</topic><topic>Colon</topic><topic>Endoscopy</topic><topic>fecal calprotectin</topic><topic>Ileum</topic><topic>Lesions</topic><topic>Lewis score</topic><topic>Mucosa</topic><topic>Original</topic><topic>pediatric Crohn’s disease</topic><topic>Pediatrics</topic><topic>Small intestine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okuhira, Takeru</creatorcontrib><creatorcontrib>Yoden, Atsushi</creatorcontrib><creatorcontrib>Aomatsu, Tomoki</creatorcontrib><creatorcontrib>Akamatsu, Masano</creatorcontrib><creatorcontrib>Inoue, Keisuke</creatorcontrib><creatorcontrib>Kaji, Emiri</creatorcontrib><creatorcontrib>Takitani, Kimitaka</creatorcontrib><creatorcontrib>Tamai, Hiroshi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okuhira, Takeru</au><au>Yoden, Atsushi</au><au>Aomatsu, Tomoki</au><au>Akamatsu, Masano</au><au>Inoue, Keisuke</au><au>Kaji, Emiri</au><au>Takitani, Kimitaka</au><au>Tamai, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of the endoscopic findings for small and large bowels in pediatric patients with established Crohn’s disease</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>64</volume><issue>3</issue><spage>257</spage><epage>264</epage><pages>257-264</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>Small bowel capsule endoscopy can detect subtle mucosal lesions in pediatric patients with Crohn’s disease, and our aim was to evaluate its application in established ileocolonic Crohn’s disease. Colonic inflammation was evaluated with the colonic Simple Endoscopic Score for Crohn’s Disease (SES-CD) (excluding the score of the terminal ileum). Small bowel inflammation was evaluated with the Lewis score and/or Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI). A Lewis score <135 was defined as small bowel inactive. A colonic SES-CD of 0 (colonic inactive group) was observed in 22/42 procedures (52.4%), and active small bowel lesions were observed in 11/22 procedures (50.0%). The Lewis score was lower in the colonic inactive group compared to the colonic active group. Correlations between the colonic SES-CD, the Lewis score and CECDAI were weak. The Lewis score and CECDAI in the colonic inactive group had significant correlation with fecal calprotectin levels. We suggest that Crohn’s disease patients without both colonic active lesions and elevation of fecal calprotectin levels may not need to receive small bowel capsule endoscopy due to low incidence of lesions in small bowel.</abstract><cop>Japan</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><pmid>31138961</pmid><doi>10.3164/jcbn.18-83</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | capsule endoscopy Colon Endoscopy fecal calprotectin Ileum Lesions Lewis score Mucosa Original pediatric Crohn’s disease Pediatrics Small intestine |
| title | Correlation of the endoscopic findings for small and large bowels in pediatric patients with established Crohn’s disease |
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