Alterations of elastin in female reproductive tissues arising from advancing parity

Female reproductive tissues undergo significant alterations during pregnancy, which may compromise the structural integrity of extracellular matrix proteins. Here, we report on modifications of elastic fibers, which are primarily composed of elastin and believed to provide a scaffold to the reproduc...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2019-05, Vol.666, p.127-137
Hauptverfasser:	Dhital, Basant, Downing, Keith T., Gul-E-Noor, Farhana, Landau, Yakov, Rathod, Pratikkumar, Hirsch, Shari, Chang, Emmanuel J., Boutis, Gregory S.
Format:	Artikel
Sprache:	eng
Schlagworte:	13C NMR Animals carbon crosslinking Desmosine Desmosine - metabolism Elastic Tissue - chemistry Elastic Tissue - metabolism Elastin Elastin - chemistry Elastin - metabolism ELISA Female females laboratory animals light microscopy MALDI mass spectrometry Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular Parity - physiology parturition Peptide Fragments - chemistry Peptide Fragments - metabolism Pregnancy Protein Structure, Secondary Rats Rats, Sprague-Dawley Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization stable isotopes Tissue Inhibitor of Metalloproteinase-1 - metabolism tissues uterus Vagina - metabolism
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