Stem cell‐derived exosomes: A promising strategy for fracture healing
Objectives To describe the biological characteristics of exosomes and to summarize the current status of stem cell‐derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed. Methods Search and analyze the related articles in pubmed database t...
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| Veröffentlicht in: | Cell proliferation 2017-10, Vol.50 (5), p.n/a |
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| container_title | Cell proliferation |
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| creator | Hao, Zi‐Chen Lu, Jun Wang, Shan‐Zheng Wu, Hao Zhang, Yun‐Tong Xu, Shuo‐Gui |
| description | Objectives
To describe the biological characteristics of exosomes and to summarize the current status of stem cell‐derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed.
Methods
Search and analyze the related articles in pubmed database through the multi‐combination of keywords like “stem cells”,”exosomes”,”bone regeneration” and “fracture healing”.
Conclusion
Stem cell‐derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention. This strategy helps to promote proliferation and migration of cells, as well as osteogenesis and angiogenesis, in the process of bone formation. Although the exact mechanisms remain elusive, exosomal miRNAs seem to play vital roles. Future studies are required to solve multiple problems before clinical application, including comprehensive and thorough understanding of exosomes, the exact roles of exosomes in regulating bone formation, and the optimal source, dose and frequency of treatment, as well as technical and safety issues. Moreover, studies based on fracture models of large animals are could offer guidance and are in demand. |
| doi_str_mv | 10.1111/cpr.12359 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6529061</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1935087997</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5099-ea6577297ac9ef0873bec29330ad11f827a2878209b475cfd1f3ce10ab2ca95f3</originalsourceid><addsrcrecordid>eNp1kctKxDAYhYMoOl4WvoAU3OiiYy6TpnEhyOANBMXLOmTSP2OlbcakVWfnI_iMPonRGUUFs8ni_zh8h4PQJsF9Et-emfg-oYzLBdQjLOMpJflgEfWwzHAqBKUraDWEe4wJIyJbRis0FwMieN5DJ9ct1ImBqnp7eS3Al49QJPDsgqsh7CeHycS7ugxlM05C63UL42linU-s16btPCR3oKt4XUdLVlcBNub_Gro9ProZnqbnFydnw8Pz1HAsZQo641FICm0kWJwLNgJDJWNYF4TYnAod3XKK5WgguLEFscwAwXpEjZbcsjV0MMuddKMaCgNNtKrUxJe19lPldKl-X5ryTo3do8o4lTgjMWBnHuDdQwehVbHeR3_dgOuCIpIyEkE6iOj2H_Tedb6J9SLFeLSXUkRqd0YZ70LwYL9lCFYf86g4j_qcJ7JbP-2_ya89IrA3A57KCqb_J6nh5dUs8h381ZsE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1935087997</pqid></control><display><type>article</type><title>Stem cell‐derived exosomes: A promising strategy for fracture healing</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>PubMed Central</source><creator>Hao, Zi‐Chen ; Lu, Jun ; Wang, Shan‐Zheng ; Wu, Hao ; Zhang, Yun‐Tong ; Xu, Shuo‐Gui</creator><creatorcontrib>Hao, Zi‐Chen ; Lu, Jun ; Wang, Shan‐Zheng ; Wu, Hao ; Zhang, Yun‐Tong ; Xu, Shuo‐Gui</creatorcontrib><description>Objectives
To describe the biological characteristics of exosomes and to summarize the current status of stem cell‐derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed.
Methods
Search and analyze the related articles in pubmed database through the multi‐combination of keywords like “stem cells”,”exosomes”,”bone regeneration” and “fracture healing”.
Conclusion
Stem cell‐derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention. This strategy helps to promote proliferation and migration of cells, as well as osteogenesis and angiogenesis, in the process of bone formation. Although the exact mechanisms remain elusive, exosomal miRNAs seem to play vital roles. Future studies are required to solve multiple problems before clinical application, including comprehensive and thorough understanding of exosomes, the exact roles of exosomes in regulating bone formation, and the optimal source, dose and frequency of treatment, as well as technical and safety issues. Moreover, studies based on fracture models of large animals are could offer guidance and are in demand.</description><identifier>ISSN: 0960-7722</identifier><identifier>EISSN: 1365-2184</identifier><identifier>DOI: 10.1111/cpr.12359</identifier><identifier>PMID: 28741758</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Angiogenesis ; Animal models ; Animals ; Biocompatibility ; Biomedical materials ; Bone growth ; Bone healing ; Bone Regeneration ; Cell Differentiation ; Cell Movement ; Cell Proliferation ; Exosomes ; Exosomes - genetics ; Exosomes - metabolism ; Exosomes - transplantation ; Fracture Healing ; Fractures ; Healing ; Humans ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Neovascularization, Physiologic ; Osteogenesis ; Regeneration ; Regeneration (physiology) ; Regenerative Medicine - methods ; Review ; Stem cell transplantation ; Stem cells ; Stem Cells - cytology ; Stem Cells - metabolism</subject><ispartof>Cell proliferation, 2017-10, Vol.50 (5), p.n/a</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5099-ea6577297ac9ef0873bec29330ad11f827a2878209b475cfd1f3ce10ab2ca95f3</citedby><cites>FETCH-LOGICAL-c5099-ea6577297ac9ef0873bec29330ad11f827a2878209b475cfd1f3ce10ab2ca95f3</cites><orcidid>0000-0003-2713-2460</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529061/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529061/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28741758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hao, Zi‐Chen</creatorcontrib><creatorcontrib>Lu, Jun</creatorcontrib><creatorcontrib>Wang, Shan‐Zheng</creatorcontrib><creatorcontrib>Wu, Hao</creatorcontrib><creatorcontrib>Zhang, Yun‐Tong</creatorcontrib><creatorcontrib>Xu, Shuo‐Gui</creatorcontrib><title>Stem cell‐derived exosomes: A promising strategy for fracture healing</title><title>Cell proliferation</title><addtitle>Cell Prolif</addtitle><description>Objectives
To describe the biological characteristics of exosomes and to summarize the current status of stem cell‐derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed.
Methods
Search and analyze the related articles in pubmed database through the multi‐combination of keywords like “stem cells”,”exosomes”,”bone regeneration” and “fracture healing”.
Conclusion
Stem cell‐derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention. This strategy helps to promote proliferation and migration of cells, as well as osteogenesis and angiogenesis, in the process of bone formation. Although the exact mechanisms remain elusive, exosomal miRNAs seem to play vital roles. Future studies are required to solve multiple problems before clinical application, including comprehensive and thorough understanding of exosomes, the exact roles of exosomes in regulating bone formation, and the optimal source, dose and frequency of treatment, as well as technical and safety issues. Moreover, studies based on fracture models of large animals are could offer guidance and are in demand.</description><subject>Angiogenesis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bone growth</subject><subject>Bone healing</subject><subject>Bone Regeneration</subject><subject>Cell Differentiation</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Exosomes</subject><subject>Exosomes - genetics</subject><subject>Exosomes - metabolism</subject><subject>Exosomes - transplantation</subject><subject>Fracture Healing</subject><subject>Fractures</subject><subject>Healing</subject><subject>Humans</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Neovascularization, Physiologic</subject><subject>Osteogenesis</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Regenerative Medicine - methods</subject><subject>Review</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><issn>0960-7722</issn><issn>1365-2184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKxDAYhYMoOl4WvoAU3OiiYy6TpnEhyOANBMXLOmTSP2OlbcakVWfnI_iMPonRGUUFs8ni_zh8h4PQJsF9Et-emfg-oYzLBdQjLOMpJflgEfWwzHAqBKUraDWEe4wJIyJbRis0FwMieN5DJ9ct1ImBqnp7eS3Al49QJPDsgqsh7CeHycS7ugxlM05C63UL42linU-s16btPCR3oKt4XUdLVlcBNub_Gro9ProZnqbnFydnw8Pz1HAsZQo641FICm0kWJwLNgJDJWNYF4TYnAod3XKK5WgguLEFscwAwXpEjZbcsjV0MMuddKMaCgNNtKrUxJe19lPldKl-X5ryTo3do8o4lTgjMWBnHuDdQwehVbHeR3_dgOuCIpIyEkE6iOj2H_Tedb6J9SLFeLSXUkRqd0YZ70LwYL9lCFYf86g4j_qcJ7JbP-2_ya89IrA3A57KCqb_J6nh5dUs8h381ZsE</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Hao, Zi‐Chen</creator><creator>Lu, Jun</creator><creator>Wang, Shan‐Zheng</creator><creator>Wu, Hao</creator><creator>Zhang, Yun‐Tong</creator><creator>Xu, Shuo‐Gui</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2713-2460</orcidid></search><sort><creationdate>201710</creationdate><title>Stem cell‐derived exosomes: A promising strategy for fracture healing</title><author>Hao, Zi‐Chen ; Lu, Jun ; Wang, Shan‐Zheng ; Wu, Hao ; Zhang, Yun‐Tong ; Xu, Shuo‐Gui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5099-ea6577297ac9ef0873bec29330ad11f827a2878209b475cfd1f3ce10ab2ca95f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Angiogenesis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Bone growth</topic><topic>Bone healing</topic><topic>Bone Regeneration</topic><topic>Cell Differentiation</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Exosomes</topic><topic>Exosomes - genetics</topic><topic>Exosomes - metabolism</topic><topic>Exosomes - transplantation</topic><topic>Fracture Healing</topic><topic>Fractures</topic><topic>Healing</topic><topic>Humans</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Neovascularization, Physiologic</topic><topic>Osteogenesis</topic><topic>Regeneration</topic><topic>Regeneration (physiology)</topic><topic>Regenerative Medicine - methods</topic><topic>Review</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hao, Zi‐Chen</creatorcontrib><creatorcontrib>Lu, Jun</creatorcontrib><creatorcontrib>Wang, Shan‐Zheng</creatorcontrib><creatorcontrib>Wu, Hao</creatorcontrib><creatorcontrib>Zhang, Yun‐Tong</creatorcontrib><creatorcontrib>Xu, Shuo‐Gui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell proliferation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hao, Zi‐Chen</au><au>Lu, Jun</au><au>Wang, Shan‐Zheng</au><au>Wu, Hao</au><au>Zhang, Yun‐Tong</au><au>Xu, Shuo‐Gui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stem cell‐derived exosomes: A promising strategy for fracture healing</atitle><jtitle>Cell proliferation</jtitle><addtitle>Cell Prolif</addtitle><date>2017-10</date><risdate>2017</risdate><volume>50</volume><issue>5</issue><epage>n/a</epage><issn>0960-7722</issn><eissn>1365-2184</eissn><abstract>Objectives
To describe the biological characteristics of exosomes and to summarize the current status of stem cell‐derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed.
Methods
Search and analyze the related articles in pubmed database through the multi‐combination of keywords like “stem cells”,”exosomes”,”bone regeneration” and “fracture healing”.
Conclusion
Stem cell‐derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention. This strategy helps to promote proliferation and migration of cells, as well as osteogenesis and angiogenesis, in the process of bone formation. Although the exact mechanisms remain elusive, exosomal miRNAs seem to play vital roles. Future studies are required to solve multiple problems before clinical application, including comprehensive and thorough understanding of exosomes, the exact roles of exosomes in regulating bone formation, and the optimal source, dose and frequency of treatment, as well as technical and safety issues. Moreover, studies based on fracture models of large animals are could offer guidance and are in demand.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>28741758</pmid><doi>10.1111/cpr.12359</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2713-2460</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; PubMed Central |
| subjects | Angiogenesis Animal models Animals Biocompatibility Biomedical materials Bone growth Bone healing Bone Regeneration Cell Differentiation Cell Movement Cell Proliferation Exosomes Exosomes - genetics Exosomes - metabolism Exosomes - transplantation Fracture Healing Fractures Healing Humans MicroRNAs - genetics MicroRNAs - metabolism Neovascularization, Physiologic Osteogenesis Regeneration Regeneration (physiology) Regenerative Medicine - methods Review Stem cell transplantation Stem cells Stem Cells - cytology Stem Cells - metabolism |
| title | Stem cell‐derived exosomes: A promising strategy for fracture healing |
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