The BRAF activated non‐coding RNA: A pivotal long non‐coding RNA in human malignancies
Long non‐coding RNAs (lncRNAs) participate in the complex network of cancer and play an important role in tumourigenesis and progression. BRAF activated non‐coding RNA (BANCR), a 4‐exon transcript of 693‐bp, was first discovered as an oncogenic long non‐coding RNA in BRAFV600E melanomas cells in 201...
Gespeichert in:
| Veröffentlicht in: | Cell proliferation 2018-08, Vol.51 (4), p.e12449-n/a |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 4 |
| container_start_page | e12449 |
| container_title | Cell proliferation |
| container_volume | 51 |
| creator | Liu, Xiu‐Fen Hao, Ji‐Long Xie, Tian Pant, Om Prakash Lu, Cheng‐Bo Lu, Cheng‐Wei Zhou, Dan‐Dan |
| description | Long non‐coding RNAs (lncRNAs) participate in the complex network of cancer and play an important role in tumourigenesis and progression. BRAF activated non‐coding RNA (BANCR), a 4‐exon transcript of 693‐bp, was first discovered as an oncogenic long non‐coding RNA in BRAFV600E melanomas cells in 2012 and was related to melanoma cell migration. Besides melanoma, increasing evidence has explored the potential role of BANCR in the development and progression of multiple other human malignancies, such as retinoblastoma, lung cancer, gastric cancer etc. since its discovery. The expression pattern of BANCR varies in different types of cancers, either as a tumour suppressor or as an accelerator. Functional BANCR may serve as a promising biomarker for cancer diagnosis as well as prognosis evaluation. BANCR‐targeted intervention may also become a valuable novel therapeutic tool against human malignancies. This review summarized the advanced research progresses concerning the expression and role of BANCR in different human malignancies. |
| doi_str_mv | 10.1111/cpr.12449 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6528848</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2076017783</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4439-3db88037b635efe7dcb34d209ba7e50df131326b95ab0870db1d28eb526787a13</originalsourceid><addsrcrecordid>eNp1kctKHEEUhgsx6HhZ5AVCgRuzaK1bd1VnIYxDjAGJMujGTVG3mSnprhq7uie48xHyjHmSVBwjRvBsCk59fPyHH4CPGB3hPMdm2R1hwli9AUaYVmVBsGCbYITqChWcE7INdlK6QwhTzKstsE1qJhinfARurxcOnk7HZ1CZ3q9U7ywMMfx-_GWi9WEOpz_GX-AYLv0q9qqBTcy7twD0AS6GVgXYqsbPgwrGu7QHPsxUk9z-87sLbs6-Xk_Oi4vLb98n44vCMEbrglotBKJcV7R0M8et0ZRZgmqtuCuRneXQlFS6LpVGgiOrsSXC6ZJUXHCF6S44WXuXg26dNS70nWrksvOt6h5kVF7-_xP8Qs7jSlYlEYKJLDh8FnTxfnCpl61PxjWNCi4OSRKEhKiRICSjB2_Quzh0IZ-XKV4hzLmgmfq8pkwXU-rc7CUMRvJvYzI3Jp8ay-yn1-lfyH8VZeB4Dfz0jXt43yQnV9O18g9lKaC3</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2076017783</pqid></control><display><type>article</type><title>The BRAF activated non‐coding RNA: A pivotal long non‐coding RNA in human malignancies</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>PubMed Central</source><creator>Liu, Xiu‐Fen ; Hao, Ji‐Long ; Xie, Tian ; Pant, Om Prakash ; Lu, Cheng‐Bo ; Lu, Cheng‐Wei ; Zhou, Dan‐Dan</creator><creatorcontrib>Liu, Xiu‐Fen ; Hao, Ji‐Long ; Xie, Tian ; Pant, Om Prakash ; Lu, Cheng‐Bo ; Lu, Cheng‐Wei ; Zhou, Dan‐Dan</creatorcontrib><description>Long non‐coding RNAs (lncRNAs) participate in the complex network of cancer and play an important role in tumourigenesis and progression. BRAF activated non‐coding RNA (BANCR), a 4‐exon transcript of 693‐bp, was first discovered as an oncogenic long non‐coding RNA in BRAFV600E melanomas cells in 2012 and was related to melanoma cell migration. Besides melanoma, increasing evidence has explored the potential role of BANCR in the development and progression of multiple other human malignancies, such as retinoblastoma, lung cancer, gastric cancer etc. since its discovery. The expression pattern of BANCR varies in different types of cancers, either as a tumour suppressor or as an accelerator. Functional BANCR may serve as a promising biomarker for cancer diagnosis as well as prognosis evaluation. BANCR‐targeted intervention may also become a valuable novel therapeutic tool against human malignancies. This review summarized the advanced research progresses concerning the expression and role of BANCR in different human malignancies.</description><identifier>ISSN: 0960-7722</identifier><identifier>EISSN: 1365-2184</identifier><identifier>DOI: 10.1111/cpr.12449</identifier><identifier>PMID: 29484737</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Animals ; BANCR ; Biomarkers ; Biomarkers, Tumor - genetics ; Cadherins - metabolism ; Cancer ; Cell adhesion & migration ; Cell migration ; Gastric cancer ; Humans ; long noncoding RNAs (lncRNAs) ; Lung cancer ; Melanoma ; Melanoma - genetics ; Melanoma - metabolism ; Melanoma - pathology ; Mitogen-Activated Protein Kinases - metabolism ; Neoplasms - genetics ; Neoplasms - metabolism ; Neoplasms - pathology ; Retina ; Retinoblastoma ; Review ; Ribonucleic acid ; RNA ; RNA Interference ; RNA, Long Noncoding - antagonists & inhibitors ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Signal Transduction ; Transcription ; Tumorigenesis ; Tumors ; tumour accelerator ; tumour suppressor</subject><ispartof>Cell proliferation, 2018-08, Vol.51 (4), p.e12449-n/a</ispartof><rights>2018 John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4439-3db88037b635efe7dcb34d209ba7e50df131326b95ab0870db1d28eb526787a13</citedby><cites>FETCH-LOGICAL-c4439-3db88037b635efe7dcb34d209ba7e50df131326b95ab0870db1d28eb526787a13</cites><orcidid>0000-0002-8370-7276</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528848/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528848/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27903,27904,45553,45554,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29484737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xiu‐Fen</creatorcontrib><creatorcontrib>Hao, Ji‐Long</creatorcontrib><creatorcontrib>Xie, Tian</creatorcontrib><creatorcontrib>Pant, Om Prakash</creatorcontrib><creatorcontrib>Lu, Cheng‐Bo</creatorcontrib><creatorcontrib>Lu, Cheng‐Wei</creatorcontrib><creatorcontrib>Zhou, Dan‐Dan</creatorcontrib><title>The BRAF activated non‐coding RNA: A pivotal long non‐coding RNA in human malignancies</title><title>Cell proliferation</title><addtitle>Cell Prolif</addtitle><description>Long non‐coding RNAs (lncRNAs) participate in the complex network of cancer and play an important role in tumourigenesis and progression. BRAF activated non‐coding RNA (BANCR), a 4‐exon transcript of 693‐bp, was first discovered as an oncogenic long non‐coding RNA in BRAFV600E melanomas cells in 2012 and was related to melanoma cell migration. Besides melanoma, increasing evidence has explored the potential role of BANCR in the development and progression of multiple other human malignancies, such as retinoblastoma, lung cancer, gastric cancer etc. since its discovery. The expression pattern of BANCR varies in different types of cancers, either as a tumour suppressor or as an accelerator. Functional BANCR may serve as a promising biomarker for cancer diagnosis as well as prognosis evaluation. BANCR‐targeted intervention may also become a valuable novel therapeutic tool against human malignancies. This review summarized the advanced research progresses concerning the expression and role of BANCR in different human malignancies.</description><subject>Animals</subject><subject>BANCR</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cadherins - metabolism</subject><subject>Cancer</subject><subject>Cell adhesion & migration</subject><subject>Cell migration</subject><subject>Gastric cancer</subject><subject>Humans</subject><subject>long noncoding RNAs (lncRNAs)</subject><subject>Lung cancer</subject><subject>Melanoma</subject><subject>Melanoma - genetics</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - pathology</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Retina</subject><subject>Retinoblastoma</subject><subject>Review</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA Interference</subject><subject>RNA, Long Noncoding - antagonists & inhibitors</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Signal Transduction</subject><subject>Transcription</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><subject>tumour accelerator</subject><subject>tumour suppressor</subject><issn>0960-7722</issn><issn>1365-2184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKHEEUhgsx6HhZ5AVCgRuzaK1bd1VnIYxDjAGJMujGTVG3mSnprhq7uie48xHyjHmSVBwjRvBsCk59fPyHH4CPGB3hPMdm2R1hwli9AUaYVmVBsGCbYITqChWcE7INdlK6QwhTzKstsE1qJhinfARurxcOnk7HZ1CZ3q9U7ywMMfx-_GWi9WEOpz_GX-AYLv0q9qqBTcy7twD0AS6GVgXYqsbPgwrGu7QHPsxUk9z-87sLbs6-Xk_Oi4vLb98n44vCMEbrglotBKJcV7R0M8et0ZRZgmqtuCuRneXQlFS6LpVGgiOrsSXC6ZJUXHCF6S44WXuXg26dNS70nWrksvOt6h5kVF7-_xP8Qs7jSlYlEYKJLDh8FnTxfnCpl61PxjWNCi4OSRKEhKiRICSjB2_Quzh0IZ-XKV4hzLmgmfq8pkwXU-rc7CUMRvJvYzI3Jp8ay-yn1-lfyH8VZeB4Dfz0jXt43yQnV9O18g9lKaC3</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Liu, Xiu‐Fen</creator><creator>Hao, Ji‐Long</creator><creator>Xie, Tian</creator><creator>Pant, Om Prakash</creator><creator>Lu, Cheng‐Bo</creator><creator>Lu, Cheng‐Wei</creator><creator>Zhou, Dan‐Dan</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8370-7276</orcidid></search><sort><creationdate>201808</creationdate><title>The BRAF activated non‐coding RNA: A pivotal long non‐coding RNA in human malignancies</title><author>Liu, Xiu‐Fen ; Hao, Ji‐Long ; Xie, Tian ; Pant, Om Prakash ; Lu, Cheng‐Bo ; Lu, Cheng‐Wei ; Zhou, Dan‐Dan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4439-3db88037b635efe7dcb34d209ba7e50df131326b95ab0870db1d28eb526787a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>BANCR</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cadherins - metabolism</topic><topic>Cancer</topic><topic>Cell adhesion & migration</topic><topic>Cell migration</topic><topic>Gastric cancer</topic><topic>Humans</topic><topic>long noncoding RNAs (lncRNAs)</topic><topic>Lung cancer</topic><topic>Melanoma</topic><topic>Melanoma - genetics</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - pathology</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Retina</topic><topic>Retinoblastoma</topic><topic>Review</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA Interference</topic><topic>RNA, Long Noncoding - antagonists & inhibitors</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Signal Transduction</topic><topic>Transcription</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><topic>tumour accelerator</topic><topic>tumour suppressor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xiu‐Fen</creatorcontrib><creatorcontrib>Hao, Ji‐Long</creatorcontrib><creatorcontrib>Xie, Tian</creatorcontrib><creatorcontrib>Pant, Om Prakash</creatorcontrib><creatorcontrib>Lu, Cheng‐Bo</creatorcontrib><creatorcontrib>Lu, Cheng‐Wei</creatorcontrib><creatorcontrib>Zhou, Dan‐Dan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell proliferation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xiu‐Fen</au><au>Hao, Ji‐Long</au><au>Xie, Tian</au><au>Pant, Om Prakash</au><au>Lu, Cheng‐Bo</au><au>Lu, Cheng‐Wei</au><au>Zhou, Dan‐Dan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The BRAF activated non‐coding RNA: A pivotal long non‐coding RNA in human malignancies</atitle><jtitle>Cell proliferation</jtitle><addtitle>Cell Prolif</addtitle><date>2018-08</date><risdate>2018</risdate><volume>51</volume><issue>4</issue><spage>e12449</spage><epage>n/a</epage><pages>e12449-n/a</pages><issn>0960-7722</issn><eissn>1365-2184</eissn><abstract>Long non‐coding RNAs (lncRNAs) participate in the complex network of cancer and play an important role in tumourigenesis and progression. BRAF activated non‐coding RNA (BANCR), a 4‐exon transcript of 693‐bp, was first discovered as an oncogenic long non‐coding RNA in BRAFV600E melanomas cells in 2012 and was related to melanoma cell migration. Besides melanoma, increasing evidence has explored the potential role of BANCR in the development and progression of multiple other human malignancies, such as retinoblastoma, lung cancer, gastric cancer etc. since its discovery. The expression pattern of BANCR varies in different types of cancers, either as a tumour suppressor or as an accelerator. Functional BANCR may serve as a promising biomarker for cancer diagnosis as well as prognosis evaluation. BANCR‐targeted intervention may also become a valuable novel therapeutic tool against human malignancies. This review summarized the advanced research progresses concerning the expression and role of BANCR in different human malignancies.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>29484737</pmid><doi>10.1111/cpr.12449</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8370-7276</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-7722 |
| ispartof | Cell proliferation, 2018-08, Vol.51 (4), p.e12449-n/a |
| issn | 0960-7722 1365-2184 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6528848 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; PubMed Central |
| subjects | Animals BANCR Biomarkers Biomarkers, Tumor - genetics Cadherins - metabolism Cancer Cell adhesion & migration Cell migration Gastric cancer Humans long noncoding RNAs (lncRNAs) Lung cancer Melanoma Melanoma - genetics Melanoma - metabolism Melanoma - pathology Mitogen-Activated Protein Kinases - metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Retina Retinoblastoma Review Ribonucleic acid RNA RNA Interference RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction Transcription Tumorigenesis Tumors tumour accelerator tumour suppressor |
| title | The BRAF activated non‐coding RNA: A pivotal long non‐coding RNA in human malignancies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T18%3A51%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20BRAF%20activated%20non%E2%80%90coding%20RNA:%20A%20pivotal%20long%20non%E2%80%90coding%20RNA%20in%20human%20malignancies&rft.jtitle=Cell%20proliferation&rft.au=Liu,%20Xiu%E2%80%90Fen&rft.date=2018-08&rft.volume=51&rft.issue=4&rft.spage=e12449&rft.epage=n/a&rft.pages=e12449-n/a&rft.issn=0960-7722&rft.eissn=1365-2184&rft_id=info:doi/10.1111/cpr.12449&rft_dat=%3Cproquest_pubme%3E2076017783%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2076017783&rft_id=info:pmid/29484737&rfr_iscdi=true |