Choroidal Microvascular Dropout in Pseudoexfoliation Glaucoma
To compare the prevalence of choroidal microvasculature dropout (CMvD) in pseudoexfoliation glaucoma (PXG) and disease severity-matched primary open-angle glaucoma (POAG) eyes. In a cross-sectional study, 39 eyes with PXG (33 patients) and 39 glaucoma severity-matched POAG eyes (34 patients) underwe...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2019-05, Vol.60 (6), p.2146-2151 |
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| creator | Pradhan, Zia S Rao, Harsha L Dixit, Shivani Sreenivasaiah, Shruthi Reddy, Praveena G Venugopal, Jayasree P Puttaiah, Narendra K Devi, Sathi Weinreb, Robert N Mansouri, Kaweh Webers, Carroll A B |
| description | To compare the prevalence of choroidal microvasculature dropout (CMvD) in pseudoexfoliation glaucoma (PXG) and disease severity-matched primary open-angle glaucoma (POAG) eyes.
In a cross-sectional study, 39 eyes with PXG (33 patients) and 39 glaucoma severity-matched POAG eyes (34 patients) underwent visual fields, optical coherence tomography and optical coherence tomography angiography examination. Peripapillary vessel density (VD) was evaluated from the radial peripapillary capillary slab, parafoveal VD was measured on the superficial vascular plexus slab of the macula, and CMvD was evaluated on the choroidal slabs of the optic disc scan.
The PXG and POAG groups were similar with respect to average mean deviation on visual fields (-12.1 vs. -12.0 decibel, P = 0.96) and average peripapillary retinal nerve fiber layer thickness on optical coherence tomography (71 vs. 74 μ, P = 0.29). Average peripapillary superficial VD (49.7% vs. 51.3%, P = 0.35) and parafoveal VD (44.8% vs. 45.8%, P = 0.33) were similar between the PXG and POAG groups. CMvD was seen in 18 PXG and 31 POAG eyes (46.2% vs. 79.5%, P = 0.002). On multivariate analysis that accounted for the severity of glaucoma, the odds of CMvD was significantly lower in the PXG group when compared with the POAG group (odds ratio: 0.18-0.21, P < 0.01).
The prevalence of CMvD was significantly lower in the PXG eyes when compared with the POAG eyes. |
| doi_str_mv | 10.1167/iovs.19-26844 |
| format | Article |
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In a cross-sectional study, 39 eyes with PXG (33 patients) and 39 glaucoma severity-matched POAG eyes (34 patients) underwent visual fields, optical coherence tomography and optical coherence tomography angiography examination. Peripapillary vessel density (VD) was evaluated from the radial peripapillary capillary slab, parafoveal VD was measured on the superficial vascular plexus slab of the macula, and CMvD was evaluated on the choroidal slabs of the optic disc scan.
The PXG and POAG groups were similar with respect to average mean deviation on visual fields (-12.1 vs. -12.0 decibel, P = 0.96) and average peripapillary retinal nerve fiber layer thickness on optical coherence tomography (71 vs. 74 μ, P = 0.29). Average peripapillary superficial VD (49.7% vs. 51.3%, P = 0.35) and parafoveal VD (44.8% vs. 45.8%, P = 0.33) were similar between the PXG and POAG groups. CMvD was seen in 18 PXG and 31 POAG eyes (46.2% vs. 79.5%, P = 0.002). On multivariate analysis that accounted for the severity of glaucoma, the odds of CMvD was significantly lower in the PXG group when compared with the POAG group (odds ratio: 0.18-0.21, P < 0.01).
The prevalence of CMvD was significantly lower in the PXG eyes when compared with the POAG eyes.</description><identifier>ISSN: 1552-5783</identifier><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.19-26844</identifier><identifier>PMID: 31108546</identifier><language>eng</language><publisher>United States: The Association for Research in Vision and Ophthalmology</publisher><subject>Adult ; Aged ; Choroid - blood supply ; Choroid Diseases - epidemiology ; Choroid Diseases - pathology ; Cross-Sectional Studies ; Exfoliation Syndrome - pathology ; Female ; Glaucoma ; Glaucoma, Open-Angle - pathology ; Humans ; India - epidemiology ; Male ; Microvessels - pathology ; Middle Aged ; Prevalence ; Prospective Studies ; Retinal Vessels - pathology ; Tomography, Optical Coherence ; Visual Fields</subject><ispartof>Investigative ophthalmology & visual science, 2019-05, Vol.60 (6), p.2146-2151</ispartof><rights>Copyright 2019 The Authors 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-6b32f7eda76c9e8dae60f05af04f9f09a93b626b27f7a6d0930fef15134830343</citedby><cites>FETCH-LOGICAL-c387t-6b32f7eda76c9e8dae60f05af04f9f09a93b626b27f7a6d0930fef15134830343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528839/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528839/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31108546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pradhan, Zia S</creatorcontrib><creatorcontrib>Rao, Harsha L</creatorcontrib><creatorcontrib>Dixit, Shivani</creatorcontrib><creatorcontrib>Sreenivasaiah, Shruthi</creatorcontrib><creatorcontrib>Reddy, Praveena G</creatorcontrib><creatorcontrib>Venugopal, Jayasree P</creatorcontrib><creatorcontrib>Puttaiah, Narendra K</creatorcontrib><creatorcontrib>Devi, Sathi</creatorcontrib><creatorcontrib>Weinreb, Robert N</creatorcontrib><creatorcontrib>Mansouri, Kaweh</creatorcontrib><creatorcontrib>Webers, Carroll A B</creatorcontrib><title>Choroidal Microvascular Dropout in Pseudoexfoliation Glaucoma</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To compare the prevalence of choroidal microvasculature dropout (CMvD) in pseudoexfoliation glaucoma (PXG) and disease severity-matched primary open-angle glaucoma (POAG) eyes.
In a cross-sectional study, 39 eyes with PXG (33 patients) and 39 glaucoma severity-matched POAG eyes (34 patients) underwent visual fields, optical coherence tomography and optical coherence tomography angiography examination. Peripapillary vessel density (VD) was evaluated from the radial peripapillary capillary slab, parafoveal VD was measured on the superficial vascular plexus slab of the macula, and CMvD was evaluated on the choroidal slabs of the optic disc scan.
The PXG and POAG groups were similar with respect to average mean deviation on visual fields (-12.1 vs. -12.0 decibel, P = 0.96) and average peripapillary retinal nerve fiber layer thickness on optical coherence tomography (71 vs. 74 μ, P = 0.29). Average peripapillary superficial VD (49.7% vs. 51.3%, P = 0.35) and parafoveal VD (44.8% vs. 45.8%, P = 0.33) were similar between the PXG and POAG groups. CMvD was seen in 18 PXG and 31 POAG eyes (46.2% vs. 79.5%, P = 0.002). On multivariate analysis that accounted for the severity of glaucoma, the odds of CMvD was significantly lower in the PXG group when compared with the POAG group (odds ratio: 0.18-0.21, P < 0.01).
The prevalence of CMvD was significantly lower in the PXG eyes when compared with the POAG eyes.</description><subject>Adult</subject><subject>Aged</subject><subject>Choroid - blood supply</subject><subject>Choroid Diseases - epidemiology</subject><subject>Choroid Diseases - pathology</subject><subject>Cross-Sectional Studies</subject><subject>Exfoliation Syndrome - pathology</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - pathology</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Microvessels - pathology</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Retinal Vessels - pathology</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Fields</subject><issn>1552-5783</issn><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkDtPwzAURi0EolAYWVFGlhQ_4tcAEipQkIpggNlyEpsauXGxkwr-PSktVZnuJ92j714dAM4QHCHE-KULyzRCMsdMFMUeOEKU4pxyQfZ38gAcp_QBIUYIw0MwIAhBQQt2BK7GsxCDq7XPnlwVw1KnqvM6ZrcxLELXZq7JXpLp6mC-bPBOty402cTrrgpzfQIOrPbJnG7mELzd372OH_Lp8-RxfDPNKyJ4m7OSYMtNrTmrpBG1NgxaSLWFhZUWSi1JyTArMbdcsxpKAq2xiCJSCAJJQYbget276Mq5qSvTtFF7tYhuruO3Ctqp_5vGzdR7WCpGsRBE9gUXm4IYPjuTWjV3qTLe68aELimMCYacMEp6NF-jvY2UorHbMwiqlXK1Uq6QVL_Ke_5897ct_eeY_AC3QH7E</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Pradhan, Zia S</creator><creator>Rao, Harsha L</creator><creator>Dixit, Shivani</creator><creator>Sreenivasaiah, Shruthi</creator><creator>Reddy, Praveena G</creator><creator>Venugopal, Jayasree P</creator><creator>Puttaiah, Narendra K</creator><creator>Devi, Sathi</creator><creator>Weinreb, Robert N</creator><creator>Mansouri, Kaweh</creator><creator>Webers, Carroll A B</creator><general>The Association for Research in Vision and Ophthalmology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190501</creationdate><title>Choroidal Microvascular Dropout in Pseudoexfoliation Glaucoma</title><author>Pradhan, Zia S ; Rao, Harsha L ; Dixit, Shivani ; Sreenivasaiah, Shruthi ; Reddy, Praveena G ; Venugopal, Jayasree P ; Puttaiah, Narendra K ; Devi, Sathi ; Weinreb, Robert N ; Mansouri, Kaweh ; Webers, Carroll A B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-6b32f7eda76c9e8dae60f05af04f9f09a93b626b27f7a6d0930fef15134830343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Choroid - blood supply</topic><topic>Choroid Diseases - epidemiology</topic><topic>Choroid Diseases - pathology</topic><topic>Cross-Sectional Studies</topic><topic>Exfoliation Syndrome - pathology</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - pathology</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Male</topic><topic>Microvessels - pathology</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Retinal Vessels - pathology</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pradhan, Zia S</creatorcontrib><creatorcontrib>Rao, Harsha L</creatorcontrib><creatorcontrib>Dixit, Shivani</creatorcontrib><creatorcontrib>Sreenivasaiah, Shruthi</creatorcontrib><creatorcontrib>Reddy, Praveena G</creatorcontrib><creatorcontrib>Venugopal, Jayasree P</creatorcontrib><creatorcontrib>Puttaiah, Narendra K</creatorcontrib><creatorcontrib>Devi, Sathi</creatorcontrib><creatorcontrib>Weinreb, Robert N</creatorcontrib><creatorcontrib>Mansouri, Kaweh</creatorcontrib><creatorcontrib>Webers, Carroll A B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pradhan, Zia S</au><au>Rao, Harsha L</au><au>Dixit, Shivani</au><au>Sreenivasaiah, Shruthi</au><au>Reddy, Praveena G</au><au>Venugopal, Jayasree P</au><au>Puttaiah, Narendra K</au><au>Devi, Sathi</au><au>Weinreb, Robert N</au><au>Mansouri, Kaweh</au><au>Webers, Carroll A B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Choroidal Microvascular Dropout in Pseudoexfoliation Glaucoma</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>60</volume><issue>6</issue><spage>2146</spage><epage>2151</epage><pages>2146-2151</pages><issn>1552-5783</issn><issn>0146-0404</issn><eissn>1552-5783</eissn><abstract>To compare the prevalence of choroidal microvasculature dropout (CMvD) in pseudoexfoliation glaucoma (PXG) and disease severity-matched primary open-angle glaucoma (POAG) eyes.
In a cross-sectional study, 39 eyes with PXG (33 patients) and 39 glaucoma severity-matched POAG eyes (34 patients) underwent visual fields, optical coherence tomography and optical coherence tomography angiography examination. Peripapillary vessel density (VD) was evaluated from the radial peripapillary capillary slab, parafoveal VD was measured on the superficial vascular plexus slab of the macula, and CMvD was evaluated on the choroidal slabs of the optic disc scan.
The PXG and POAG groups were similar with respect to average mean deviation on visual fields (-12.1 vs. -12.0 decibel, P = 0.96) and average peripapillary retinal nerve fiber layer thickness on optical coherence tomography (71 vs. 74 μ, P = 0.29). Average peripapillary superficial VD (49.7% vs. 51.3%, P = 0.35) and parafoveal VD (44.8% vs. 45.8%, P = 0.33) were similar between the PXG and POAG groups. CMvD was seen in 18 PXG and 31 POAG eyes (46.2% vs. 79.5%, P = 0.002). On multivariate analysis that accounted for the severity of glaucoma, the odds of CMvD was significantly lower in the PXG group when compared with the POAG group (odds ratio: 0.18-0.21, P < 0.01).
The prevalence of CMvD was significantly lower in the PXG eyes when compared with the POAG eyes.</abstract><cop>United States</cop><pub>The Association for Research in Vision and Ophthalmology</pub><pmid>31108546</pmid><doi>10.1167/iovs.19-26844</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Aged Choroid - blood supply Choroid Diseases - epidemiology Choroid Diseases - pathology Cross-Sectional Studies Exfoliation Syndrome - pathology Female Glaucoma Glaucoma, Open-Angle - pathology Humans India - epidemiology Male Microvessels - pathology Middle Aged Prevalence Prospective Studies Retinal Vessels - pathology Tomography, Optical Coherence Visual Fields |
| title | Choroidal Microvascular Dropout in Pseudoexfoliation Glaucoma |
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