Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression

Nitric oxide (NO) stimulates soluble guanylyl cyclase (sGC) activity, leading to elevated intracellular cyclic guanosine 3′,5′-monophosphate (cGMP) and subsequent vascular smooth muscle relaxation. It is known that downregulation of sGC expression attenuates vascular dilation and contributes to the...

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Veröffentlicht in:	Molecular pharmacology 2019-06, Vol.95 (6), p.629-637
Hauptverfasser:	Galley, Joseph C., Durgin, Brittany G., Miller, Megan P., Hahn, Scott A., Yuan, Shuai, Wood, Katherine C., Straub, Adam C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - cytology Aorta, Thoracic - drug effects Cell Cycle Proteins - genetics Cells, Cultured Dose-Response Relationship, Drug Down-Regulation Forkhead Transcription Factors - antagonists & inhibitors Gene Expression Regulation - drug effects Mice Muscle Relaxation - drug effects Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Nitric Oxide - metabolism Quinolones - pharmacology Rats Soluble Guanylyl Cyclase - deficiency Soluble Guanylyl Cyclase - genetics Soluble Guanylyl Cyclase - metabolism
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