Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

Despite compelling rates of durable clinical responses to programmed cell death-1 (PD-1) blockade, advances are needed to extend these benefits to resistant tumors. We found that tumor-bearing mice deficient in the chemokine receptor CXCR3 responded poorly to anti-PD-1 treatment. CXCR3 and its ligan...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2019-06, Vol.50 (6), p.1498-1512.e5
Hauptverfasser:	Chow, Melvyn T., Ozga, Aleksandra J., Servis, Rachel L., Frederick, Dennie T., Lo, Jennifer A., Fisher, David E., Freeman, Gordon J., Boland, Genevieve M., Luster, Andrew D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antineoplastic Agents, Immunological - pharmacology Antineoplastic Agents, Immunological - therapeutic use Apoptosis Bearing Bioindicators Biomarkers Bone marrow Cancer therapies CD103 antigen CD8 antigen CD8+ T cells CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell adhesion & migration Cell death Cell interactions chemokine Chemokines CXCL10 CXCL9 CXCR3 CXCR3 protein Cytokines Dendritic cells Disease Models, Animal Epigenesis, Genetic Humans immune checkpoint Immunomodulation - drug effects Immunotherapy Infiltration Ligands Lymphocyte Activation Lymphocytes Lymphocytes T Medical research Melanoma Metastases Mice Mice, Knockout Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology PD-1 PD-1 protein Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - metabolism Receptors, CXCR3 - metabolism Scholarships & fellowships Statistical analysis T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tumor Microenvironment Tumor necrosis factor-TNF Tumors Xenograft Model Antitumor Assays
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