Carbene‐Catalyzed Enantioselective Decarboxylative Annulations to Access Dihydrobenzoxazinones and Quinolones

A direct decarboxylative strategy for the generation of aza‐o‐quinone methides (aza‐o‐QMs) by N‐heterocyclic carbene (NHC) catalysis has been discovered and explored. This process requires no stoichiometric additives in contrast with current approaches. Aza‐o‐QMs react with trifluoromethyl ketones t...

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Veröffentlicht in:	Angewandte Chemie International Edition 2019-04, Vol.58 (18), p.5941-5945
Hauptverfasser:	Lee, Ansoo, Zhu, Joshua L., Feoktistova, Taisiia, Brueckner, Alexander C., Cheong, Paul H.‐Y., Scheidt, Karl A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Additives annulation asymmetric synthesis Catalysis Chemical reactions Density functional theory Enantiomers homogeneous catalysis Ketones N-heterocyclic carbenes Organic chemistry organocatalysis Potential energy Quinolones Quinones
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