Indomethacin impairs mitochondrial dynamics by activating the PKCζ–p38–DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells

The subcellular mechanism by which nonsteroidal anti-inflammatory drugs (NSAIDs) induce apoptosis in gastric cancer and normal mucosal cells is elusive because of the diverse cyclooxygenase-independent effects of these drugs. Using human gastric carcinoma cells (AGSs) and a rat gastric injury model,...

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Veröffentlicht in:	The Journal of biological chemistry 2019-05, Vol.294 (20), p.8238-8258
Hauptverfasser:	Mazumder, Somnath, De, Rudranil, Debsharma, Subhashis, Bindu, Samik, Maity, Pallab, Sarkar, Souvik, Saha, Shubhra Jyoti, Siddiqui, Asim Azhar, Banerjee, Chinmoy, Nag, Shiladitya, Saha, Debanjan, Pramanik, Saikat, Mitra, Kalyan, Bandyopadhyay, Uday
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - drug effects Apoptosis - genetics Cell Line, Tumor dynamin-related protein 1 (DRP1) Dynamins Gastric Mucosa - enzymology Gastric Mucosa - pathology GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Humans Indomethacin - pharmacology inflammation kinase signaling MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mitochondria - enzymology Mitochondria - genetics Mitochondrial Dynamics - drug effects Mitochondrial Dynamics - genetics mitochondrial membrane potential Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism mitochondrial respiratory chain complex Neoplasm Proteins - genetics Neoplasm Proteins - metabolism oxidative stress p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Protein Kinase C - genetics Protein Kinase C - metabolism Rats Signal Transduction Stomach Neoplasms - enzymology Stomach Neoplasms - genetics Stomach Neoplasms - pathology
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