(Pro)renin receptor-mediated myocardial injury, apoptosis, and inflammatory response in rats with diabetic cardiomyopathy

Excessive activation of the renin-angiotensin system (RAS) in diabetic cardiomyopathy (DCM) provokes a series of structural and functional abnormalities, and causes ventricular remodeling and heart failure in diabetes. (Pro)renin receptor (PRR) is a component of the RAS and has been reported to be u...

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Veröffentlicht in:	The Journal of biological chemistry 2019-05, Vol.294 (20), p.8218-8226
Hauptverfasser:	Dong, Xuefei, Yu, Shiran, Wang, Ying, Yang, Min, Xiong, Jie, Hei, Naier, Dong, Bo, Su, Qing, Chen, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	(pro)renin receptor Animals Apoptosis cardiomyopathy Collagen Type I - biosynthesis diabetes Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Cardiomyopathies - metabolism Diabetic Cardiomyopathies - pathology Fibronectins - biosynthesis Fibrosis inflammation Inflammation - metabolism Inflammation - pathology Male MAP Kinase Signaling System Molecular Bases of Disease myocardial injury Myocardium - metabolism Myocardium - pathology oxidative stress Rats Rats, Wistar Reactive Oxygen Species - metabolism Receptors, Cell Surface - metabolism Renin-Angiotensin System
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