Alcohol's actions on neuronal nicotinic acetylcholine receptors
Although it has been known for many years that alcoholism and tobacco addiction often co-occur, relatively little information is available on the biological factors that regulate the co-use and abuse of nicotine and alcohol. In the brain, nicotine acts at several different types of receptors collect...
Gespeichert in:
| Veröffentlicht in: | Alcohol research & health 2006-01, Vol.29 (3), p.179-185 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 185 |
|---|---|
| container_issue | 3 |
| container_start_page | 179 |
| container_title | Alcohol research & health |
| container_volume | 29 |
| creator | Davis, Tiffany J de Fiebre, Christopher M |
| description | Although it has been known for many years that alcoholism and tobacco addiction often co-occur, relatively little information is available on the biological factors that regulate the co-use and abuse of nicotine and alcohol. In the brain, nicotine acts at several different types of receptors collectively known as nicotinic acetylcholine receptors (nAChRs). Alcohol also acts on at least some of these receptors, enhancing the function of some nAChR subtypes and inhibiting the activity of others. Chronic alcohol and nicotine administration also lead to changes in the numbers of nAChRs. Natural variations (i.e., polymorphisms) in the genes encoding different nAChR subunits may be associated with individual differences in the sensitivity to some of alcohol's and nicotine's effects. Finally, at least one subtype of nAChR may help protect cells against alcohol-induced neurotoxicity. |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6527039</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A169826676</galeid><sourcerecordid>A169826676</sourcerecordid><originalsourceid>FETCH-LOGICAL-g332t-482aa95471f68d61135a14854f64f724f63b87c0a4c6fc655527d0a1716f27233</originalsourceid><addsrcrecordid>eNptkc1KAzEURgdRbK2-ggxuxMVI_jOzUUrRKhTc6DqkaTJNmSY1yYh9eyOtYkECuSH33ANfclQMYYNBBSjHx_lMMa04gWRQnMW4AgBihuFpMYAcc0wAGxb34075pe-uYylVst7F0rvS6T54J7vSWeWTzXvu6rTtVEat02XQSm-SD_G8ODGyi_piX0fF2-PD6-Spmr1MnyfjWdVijFJFaiRlQwmHhtULBiGmEpKaEsOI4SgXPK-5ApIoZhSjlCK-ABJyyAziCONRcbfzbvr5Wi-UdinITmyCXcuwFV5acdhxdila_yFYNgHcZMHVXhD8e69jEivfh5wxCoQQbhBrvqFqB7Wy08I647NLtdrprPROG5uvx5A1NWKMs8zf_sPntdDr_HL_DdwcDGQm6c_Uyj5GUU9nh-zl38i_WX8-D38BPjqUyQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222392699</pqid></control><display><type>article</type><title>Alcohol's actions on neuronal nicotinic acetylcholine receptors</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>U.S. Government Documents</source><source>PubMed Central</source><creator>Davis, Tiffany J ; de Fiebre, Christopher M</creator><creatorcontrib>Davis, Tiffany J ; de Fiebre, Christopher M</creatorcontrib><description>Although it has been known for many years that alcoholism and tobacco addiction often co-occur, relatively little information is available on the biological factors that regulate the co-use and abuse of nicotine and alcohol. In the brain, nicotine acts at several different types of receptors collectively known as nicotinic acetylcholine receptors (nAChRs). Alcohol also acts on at least some of these receptors, enhancing the function of some nAChR subtypes and inhibiting the activity of others. Chronic alcohol and nicotine administration also lead to changes in the numbers of nAChRs. Natural variations (i.e., polymorphisms) in the genes encoding different nAChR subunits may be associated with individual differences in the sensitivity to some of alcohol's and nicotine's effects. Finally, at least one subtype of nAChR may help protect cells against alcohol-induced neurotoxicity.</description><identifier>ISSN: 1535-7414</identifier><identifier>ISSN: 2168-3492</identifier><identifier>EISSN: 1930-0573</identifier><identifier>EISSN: 2169-4796</identifier><identifier>PMID: 17373406</identifier><language>eng</language><publisher>United States: U.S. Government Printing Office</publisher><subject>Alcohol-Related Disorders - genetics ; Alcohol-Related Disorders - physiopathology ; Alcoholism ; alpha7 Nicotinic Acetylcholine Receptor ; Animals ; Biological Mechanisms ; Brain - drug effects ; Brain - physiopathology ; Drug Interactions ; Ethanol - pharmacology ; Genetic aspects ; Humans ; Mice ; Mice, Knockout ; Natural pesticides ; Neurons ; Neurons - drug effects ; Neurons - physiology ; Nicotine ; Polymorphism, Genetic - genetics ; Proteins ; Receptors, Nicotinic - drug effects ; Receptors, Nicotinic - genetics ; Receptors, Nicotinic - physiology ; Signal Transduction - drug effects ; Signal Transduction - physiology ; Studies ; Tobacco Use Disorder - genetics ; Tobacco Use Disorder - physiopathology</subject><ispartof>Alcohol research & health, 2006-01, Vol.29 (3), p.179-185</ispartof><rights>COPYRIGHT 2006 U.S. Government Printing Office</rights><rights>Copyright Superintendent of Documents 2006</rights><rights>2006</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527039/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527039/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17373406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davis, Tiffany J</creatorcontrib><creatorcontrib>de Fiebre, Christopher M</creatorcontrib><title>Alcohol's actions on neuronal nicotinic acetylcholine receptors</title><title>Alcohol research & health</title><addtitle>Alcohol Res Health</addtitle><description>Although it has been known for many years that alcoholism and tobacco addiction often co-occur, relatively little information is available on the biological factors that regulate the co-use and abuse of nicotine and alcohol. In the brain, nicotine acts at several different types of receptors collectively known as nicotinic acetylcholine receptors (nAChRs). Alcohol also acts on at least some of these receptors, enhancing the function of some nAChR subtypes and inhibiting the activity of others. Chronic alcohol and nicotine administration also lead to changes in the numbers of nAChRs. Natural variations (i.e., polymorphisms) in the genes encoding different nAChR subunits may be associated with individual differences in the sensitivity to some of alcohol's and nicotine's effects. Finally, at least one subtype of nAChR may help protect cells against alcohol-induced neurotoxicity.</description><subject>Alcohol-Related Disorders - genetics</subject><subject>Alcohol-Related Disorders - physiopathology</subject><subject>Alcoholism</subject><subject>alpha7 Nicotinic Acetylcholine Receptor</subject><subject>Animals</subject><subject>Biological Mechanisms</subject><subject>Brain - drug effects</subject><subject>Brain - physiopathology</subject><subject>Drug Interactions</subject><subject>Ethanol - pharmacology</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Natural pesticides</subject><subject>Neurons</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Nicotine</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Proteins</subject><subject>Receptors, Nicotinic - drug effects</subject><subject>Receptors, Nicotinic - genetics</subject><subject>Receptors, Nicotinic - physiology</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - physiology</subject><subject>Studies</subject><subject>Tobacco Use Disorder - genetics</subject><subject>Tobacco Use Disorder - physiopathology</subject><issn>1535-7414</issn><issn>2168-3492</issn><issn>1930-0573</issn><issn>2169-4796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkc1KAzEURgdRbK2-ggxuxMVI_jOzUUrRKhTc6DqkaTJNmSY1yYh9eyOtYkECuSH33ANfclQMYYNBBSjHx_lMMa04gWRQnMW4AgBihuFpMYAcc0wAGxb34075pe-uYylVst7F0rvS6T54J7vSWeWTzXvu6rTtVEat02XQSm-SD_G8ODGyi_piX0fF2-PD6-Spmr1MnyfjWdVijFJFaiRlQwmHhtULBiGmEpKaEsOI4SgXPK-5ApIoZhSjlCK-ABJyyAziCONRcbfzbvr5Wi-UdinITmyCXcuwFV5acdhxdila_yFYNgHcZMHVXhD8e69jEivfh5wxCoQQbhBrvqFqB7Wy08I647NLtdrprPROG5uvx5A1NWKMs8zf_sPntdDr_HL_DdwcDGQm6c_Uyj5GUU9nh-zl38i_WX8-D38BPjqUyQ</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Davis, Tiffany J</creator><creator>de Fiebre, Christopher M</creator><general>U.S. Government Printing Office</general><general>Superintendent of Documents</general><general>National Institute on Alcohol Abuse and Alcoholism</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8GL</scope><scope>0-V</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>88J</scope><scope>8AF</scope><scope>8AM</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K7.</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0O</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M2R</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>5PM</scope></search><sort><creationdate>20060101</creationdate><title>Alcohol's actions on neuronal nicotinic acetylcholine receptors</title><author>Davis, Tiffany J ; de Fiebre, Christopher M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g332t-482aa95471f68d61135a14854f64f724f63b87c0a4c6fc655527d0a1716f27233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alcohol-Related Disorders - genetics</topic><topic>Alcohol-Related Disorders - physiopathology</topic><topic>Alcoholism</topic><topic>alpha7 Nicotinic Acetylcholine Receptor</topic><topic>Animals</topic><topic>Biological Mechanisms</topic><topic>Brain - drug effects</topic><topic>Brain - physiopathology</topic><topic>Drug Interactions</topic><topic>Ethanol - pharmacology</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Natural pesticides</topic><topic>Neurons</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Nicotine</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Proteins</topic><topic>Receptors, Nicotinic - drug effects</topic><topic>Receptors, Nicotinic - genetics</topic><topic>Receptors, Nicotinic - physiology</topic><topic>Signal Transduction - drug effects</topic><topic>Signal Transduction - physiology</topic><topic>Studies</topic><topic>Tobacco Use Disorder - genetics</topic><topic>Tobacco Use Disorder - physiopathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Davis, Tiffany J</creatorcontrib><creatorcontrib>de Fiebre, Christopher M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Gale In Context: High School</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Criminology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Criminal Justice Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Social Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alcohol research & health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davis, Tiffany J</au><au>de Fiebre, Christopher M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol's actions on neuronal nicotinic acetylcholine receptors</atitle><jtitle>Alcohol research & health</jtitle><addtitle>Alcohol Res Health</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>29</volume><issue>3</issue><spage>179</spage><epage>185</epage><pages>179-185</pages><issn>1535-7414</issn><issn>2168-3492</issn><eissn>1930-0573</eissn><eissn>2169-4796</eissn><abstract>Although it has been known for many years that alcoholism and tobacco addiction often co-occur, relatively little information is available on the biological factors that regulate the co-use and abuse of nicotine and alcohol. In the brain, nicotine acts at several different types of receptors collectively known as nicotinic acetylcholine receptors (nAChRs). Alcohol also acts on at least some of these receptors, enhancing the function of some nAChR subtypes and inhibiting the activity of others. Chronic alcohol and nicotine administration also lead to changes in the numbers of nAChRs. Natural variations (i.e., polymorphisms) in the genes encoding different nAChR subunits may be associated with individual differences in the sensitivity to some of alcohol's and nicotine's effects. Finally, at least one subtype of nAChR may help protect cells against alcohol-induced neurotoxicity.</abstract><cop>United States</cop><pub>U.S. Government Printing Office</pub><pmid>17373406</pmid><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1535-7414 |
| ispartof | Alcohol research & health, 2006-01, Vol.29 (3), p.179-185 |
| issn | 1535-7414 2168-3492 1930-0573 2169-4796 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6527039 |
| source | MEDLINE; PubMed Central Open Access; U.S. Government Documents; PubMed Central |
| subjects | Alcohol-Related Disorders - genetics Alcohol-Related Disorders - physiopathology Alcoholism alpha7 Nicotinic Acetylcholine Receptor Animals Biological Mechanisms Brain - drug effects Brain - physiopathology Drug Interactions Ethanol - pharmacology Genetic aspects Humans Mice Mice, Knockout Natural pesticides Neurons Neurons - drug effects Neurons - physiology Nicotine Polymorphism, Genetic - genetics Proteins Receptors, Nicotinic - drug effects Receptors, Nicotinic - genetics Receptors, Nicotinic - physiology Signal Transduction - drug effects Signal Transduction - physiology Studies Tobacco Use Disorder - genetics Tobacco Use Disorder - physiopathology |
| title | Alcohol's actions on neuronal nicotinic acetylcholine receptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T08%3A43%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alcohol's%20actions%20on%20neuronal%20nicotinic%20acetylcholine%20receptors&rft.jtitle=Alcohol%20research%20&%20health&rft.au=Davis,%20Tiffany%20J&rft.date=2006-01-01&rft.volume=29&rft.issue=3&rft.spage=179&rft.epage=185&rft.pages=179-185&rft.issn=1535-7414&rft.eissn=1930-0573&rft_id=info:doi/&rft_dat=%3Cgale_pubme%3EA169826676%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222392699&rft_id=info:pmid/17373406&rft_galeid=A169826676&rfr_iscdi=true |