Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients with Colorectal Cancer

BACKGROUND The use of adoptive T cell therapy has proven to be effective in some advanced malignancies. This study aimed to investigate the effects of lymphocyte-activation gene 3 (LAG-3) immune checkpoint receptor in the enrichment of tumor antigen-specific CD8⁺ T lymphocytes derived from periphera...

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Veröffentlicht in:	Medical science monitor 2019-05, Vol.25, p.3495-3502
Hauptverfasser:	Huang, Lefu, Qiao, Guoliang, Wu, Jingping, Ren, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, CD - genetics Antigens, CD - metabolism Antigens, Neoplasm - metabolism CD28 Antigens - immunology CD3 Complex - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor China Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Female Flow Cytometry Humans Interferon-gamma - metabolism Lab/In Vitro Research Leukocytes, Mononuclear - metabolism Lymphocyte Activation - immunology Male Middle Aged Receptors, Antigen, T-Cell Receptors, Immunologic - metabolism
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