Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo

Moderate or severe traumatic brain injury (TBI) causes widespread neuronal cell death. Microglia, the resident macrophages of the brain, react to injury by migrating to the lesion site, where they phagocytose cellular debris. Microglial phagocytosis can have both beneficial (e.g. debris clearance) a...

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Veröffentlicht in:	Development (Cambridge) 2019-05, Vol.146 (9)
Hauptverfasser:	Herzog, Chiara, Pons Garcia, Laura, Keatinge, Marcus, Greenald, David, Moritz, Christian, Peri, Francesca, Herrgen, Leah
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - cytology Brain - metabolism Brain Injuries - metabolism Cell Death - physiology Larva - cytology Larva - metabolism Macrophages - metabolism Microglia - metabolism Neurons - cytology Neurons - metabolism Phagocytosis - physiology Stem Cells and Regeneration Zebrafish
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