Profiling of Pluripotency Factors in Single Cells and Early Embryos

Cell fate decisions are governed by sequence-specific transcription factors (TFs) that act in small populations of cells within developing embryos. To understand their functions in vivo, it is important to identify TF binding sites in these cells. However, current methods cannot profile TFs genome-w...

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Veröffentlicht in:	Cell 2019-05, Vol.177 (5), p.1319-1329.e11
Hauptverfasser:	Hainer, Sarah J., Bošković, Ana, McCannell, Kurtis N., Rando, Oliver J., Fazzio, Thomas G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals binding sites blastocyst Blastocyst - metabolism Brg1 ChIP-seq chromatin Chromatin - metabolism Chromatin Assembly and Disassembly - physiology cultured cells CUT&RUN embryo enzymes esBAF Female Gene Expression Profiling Gene Expression Regulation, Developmental - physiology Mice Nanog pluripotency stem cell transcription factor transcription factors Transcription Factors - metabolism
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