Dependence of the Formation of Tau and Aβ Peptide Mixed Aggregates on the Secondary Structure of the N‑Terminal Region of Aβ

One of the hallmarks of Alzheimer’s disease is the formation of aggregates of the tau protein, a process that can be facilitated by the presence of fibrils formed by the amyloid β peptide (Aβ). However, the mechanism that triggers tau aggregation is still a matter of debate. The effect of Aβ40 fibri...

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Veröffentlicht in:	The journal of physical chemistry. B 2018-07, Vol.122 (28), p.7049-7056
Hauptverfasser:	Rojas, Ana V, Maisuradze, Gia G, Scheraga, Harold A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Amino Acid Sequence Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Dimerization Humans Molecular Dynamics Simulation Peptide Fragments - chemistry Peptide Fragments - metabolism Protein Aggregates - physiology Protein Binding Protein Structure, Secondary tau Proteins - chemistry tau Proteins - metabolism
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