Microhomology Selection for Microhomology Mediated End Joining in Saccharomyces cerevisiae

Microhomology-mediated end joining (MMEJ) anneals short, imperfect microhomologies flanking DNA breaks, producing repair products with deletions in a Ku- and -independent fashion. Puzzlingly, MMEJ preferentially selects certain microhomologies over others, even when multiple microhomologies are avai...

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Veröffentlicht in:	Genes 2019-04, Vol.10 (4), p.284
Hauptverfasser:	Lee, Kihoon, Ji, Jae-Hoon, Yoon, Kihoon, Che, Jun, Seol, Ja-Hwan, Lee, Sang Eun, Shim, Eun Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Annealing Chromosomes DNA Breaks, Double-Stranded DNA damage DNA End-Joining Repair - genetics DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics Endonuclease Endonucleases - genetics Gene deletion Mammals MSH6 protein Rad52 DNA Repair and Recombination Protein - genetics Rad52 protein Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Sequence Deletion - genetics Telomeres Yeast
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