Thermoresponsive Poly( N -Isopropylacrylamide- co -Dimethylaminoethyl Methacrylate) Microgel Aqueous Dispersions with Potential Antimicrobial Properties
The work herein describes the preparation of thermoresponsive microgels with potential antimicrobial properties. Most of the work performed so far regarding microgels with antimicrobial activity, deals with the ability of microgels to carry and release antibiotics or antimicrobial agents (antimicrob...
Gespeichert in:
| Veröffentlicht in: | Polymers 2019-04, Vol.11 (4), p.606 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 4 |
| container_start_page | 606 |
| container_title | Polymers |
| container_volume | 11 |
| creator | Echeverría, Coro Aragón-Gutiérrez, Alejandro Fernández-García, Marta Muñoz-Bonilla, Alexandra López, Daniel |
| description | The work herein describes the preparation of thermoresponsive microgels with potential antimicrobial properties. Most of the work performed so far regarding microgels with antimicrobial activity, deals with the ability of microgels to carry and release antibiotics or antimicrobial agents (antimicrobial peptides). The originality of this work lies in the possibility of developing intrinsic antimicrobial microgels by copolymerization of the well-known thermoresponsive monomer,
-isopropylacrylamide (NIPAM) with dimethylaminoethyl methacrylate (DMAEMA), a water-soluble monomer, to form microgels via precipitation polymerization (radical polymerization). Due to the presence of a tertiary amine in the DMAEMA comonomer, microgels can be modified by
-alkylation reaction with methyl and butyl iodide. This quaternization confers positive charges to the microgel surfaces and thus the potential antimicrobial activity. The effect of DMAEMA content and its quaternization with both, methyl and butyl iodide is evaluated in terms of thermal and surface charge properties, as well as in the microgel size and viscoelastic behavior. Finally, a preliminary study of the antimicrobial activity against different microorganisms is also performed in terms of minimum inhibitory concentration (MIC). From this study we determined that in contrast with butylated microgels, methylated ones show potential antimicrobial activity and good physical properties besides of maintaining microgel thermo-responsiveness. |
| doi_str_mv | 10.3390/polym11040606 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6523738</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2557228232</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-3306e26d319bf2065ebd35c6860ecd72993e18d120c5217264322494cb2929de3</originalsourceid><addsrcrecordid>eNpdkU1P3DAQhq2qVUGUY6-VpV7gkGKPYye-VELQDySgHOjZSpxZ1iiJUztLtf-kP7ezLCDAB8_YfjTvvB7GPkrxRSkrjqbYrwcpRSmMMG_YLohKFaUy4u2zfIft53wraJXaGFm9ZztKWCO0Fbvs3_US0xAT5imOOdwhv6KaB_ySF2c5TilO677xibYhdFhwH3lxGgacl_dXY7zP-AWFLTbjIb8IPsUb7PnxnxXGVeanIU-YciAJ_jfMSxKZcZxDQwiFYcO3m9MVCWKaA-YP7N2i6TPuP8Q99vv7t-uTn8X5rx9nJ8fnhS-lngulhEEwnZK2XYAwGttOaW9qI9B3FVirUNadBOE1yApMqQBKW_oWLNgO1R77uq07rdoBO09tpaZ3UwpDk9YuNsG9fBnD0t3EO2c0qErVVODgoUCKZDfPbgjZY98348a7A-qKJGupCf38Cr2NqzSSPQdaVwA1KCCq2FL0KTknXDw1I4XbjN29GDvxn547eKIfh6z-A9dFrGg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2557228232</pqid></control><display><type>article</type><title>Thermoresponsive Poly( N -Isopropylacrylamide- co -Dimethylaminoethyl Methacrylate) Microgel Aqueous Dispersions with Potential Antimicrobial Properties</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Echeverría, Coro ; Aragón-Gutiérrez, Alejandro ; Fernández-García, Marta ; Muñoz-Bonilla, Alexandra ; López, Daniel</creator><creatorcontrib>Echeverría, Coro ; Aragón-Gutiérrez, Alejandro ; Fernández-García, Marta ; Muñoz-Bonilla, Alexandra ; López, Daniel</creatorcontrib><description>The work herein describes the preparation of thermoresponsive microgels with potential antimicrobial properties. Most of the work performed so far regarding microgels with antimicrobial activity, deals with the ability of microgels to carry and release antibiotics or antimicrobial agents (antimicrobial peptides). The originality of this work lies in the possibility of developing intrinsic antimicrobial microgels by copolymerization of the well-known thermoresponsive monomer,
-isopropylacrylamide (NIPAM) with dimethylaminoethyl methacrylate (DMAEMA), a water-soluble monomer, to form microgels via precipitation polymerization (radical polymerization). Due to the presence of a tertiary amine in the DMAEMA comonomer, microgels can be modified by
-alkylation reaction with methyl and butyl iodide. This quaternization confers positive charges to the microgel surfaces and thus the potential antimicrobial activity. The effect of DMAEMA content and its quaternization with both, methyl and butyl iodide is evaluated in terms of thermal and surface charge properties, as well as in the microgel size and viscoelastic behavior. Finally, a preliminary study of the antimicrobial activity against different microorganisms is also performed in terms of minimum inhibitory concentration (MIC). From this study we determined that in contrast with butylated microgels, methylated ones show potential antimicrobial activity and good physical properties besides of maintaining microgel thermo-responsiveness.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym11040606</identifier><identifier>PMID: 30960590</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alkylation ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; Chemical precipitation ; Copolymerization ; Design ; Drug delivery systems ; Emulsion polymerization ; Isopropylacrylamide ; Microgels ; Microorganisms ; Molecular weight ; Monomers ; Nanoparticles ; Peptides ; Physical properties ; Polymerization ; Polymers ; Surface charge ; Viscoelasticity</subject><ispartof>Polymers, 2019-04, Vol.11 (4), p.606</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-3306e26d319bf2065ebd35c6860ecd72993e18d120c5217264322494cb2929de3</citedby><cites>FETCH-LOGICAL-c415t-3306e26d319bf2065ebd35c6860ecd72993e18d120c5217264322494cb2929de3</cites><orcidid>0000-0001-6386-5798</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523738/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523738/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30960590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Echeverría, Coro</creatorcontrib><creatorcontrib>Aragón-Gutiérrez, Alejandro</creatorcontrib><creatorcontrib>Fernández-García, Marta</creatorcontrib><creatorcontrib>Muñoz-Bonilla, Alexandra</creatorcontrib><creatorcontrib>López, Daniel</creatorcontrib><title>Thermoresponsive Poly( N -Isopropylacrylamide- co -Dimethylaminoethyl Methacrylate) Microgel Aqueous Dispersions with Potential Antimicrobial Properties</title><title>Polymers</title><addtitle>Polymers (Basel)</addtitle><description>The work herein describes the preparation of thermoresponsive microgels with potential antimicrobial properties. Most of the work performed so far regarding microgels with antimicrobial activity, deals with the ability of microgels to carry and release antibiotics or antimicrobial agents (antimicrobial peptides). The originality of this work lies in the possibility of developing intrinsic antimicrobial microgels by copolymerization of the well-known thermoresponsive monomer,
-isopropylacrylamide (NIPAM) with dimethylaminoethyl methacrylate (DMAEMA), a water-soluble monomer, to form microgels via precipitation polymerization (radical polymerization). Due to the presence of a tertiary amine in the DMAEMA comonomer, microgels can be modified by
-alkylation reaction with methyl and butyl iodide. This quaternization confers positive charges to the microgel surfaces and thus the potential antimicrobial activity. The effect of DMAEMA content and its quaternization with both, methyl and butyl iodide is evaluated in terms of thermal and surface charge properties, as well as in the microgel size and viscoelastic behavior. Finally, a preliminary study of the antimicrobial activity against different microorganisms is also performed in terms of minimum inhibitory concentration (MIC). From this study we determined that in contrast with butylated microgels, methylated ones show potential antimicrobial activity and good physical properties besides of maintaining microgel thermo-responsiveness.</description><subject>Alkylation</subject><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Chemical precipitation</subject><subject>Copolymerization</subject><subject>Design</subject><subject>Drug delivery systems</subject><subject>Emulsion polymerization</subject><subject>Isopropylacrylamide</subject><subject>Microgels</subject><subject>Microorganisms</subject><subject>Molecular weight</subject><subject>Monomers</subject><subject>Nanoparticles</subject><subject>Peptides</subject><subject>Physical properties</subject><subject>Polymerization</subject><subject>Polymers</subject><subject>Surface charge</subject><subject>Viscoelasticity</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU1P3DAQhq2qVUGUY6-VpV7gkGKPYye-VELQDySgHOjZSpxZ1iiJUztLtf-kP7ezLCDAB8_YfjTvvB7GPkrxRSkrjqbYrwcpRSmMMG_YLohKFaUy4u2zfIft53wraJXaGFm9ZztKWCO0Fbvs3_US0xAT5imOOdwhv6KaB_ySF2c5TilO677xibYhdFhwH3lxGgacl_dXY7zP-AWFLTbjIb8IPsUb7PnxnxXGVeanIU-YciAJ_jfMSxKZcZxDQwiFYcO3m9MVCWKaA-YP7N2i6TPuP8Q99vv7t-uTn8X5rx9nJ8fnhS-lngulhEEwnZK2XYAwGttOaW9qI9B3FVirUNadBOE1yApMqQBKW_oWLNgO1R77uq07rdoBO09tpaZ3UwpDk9YuNsG9fBnD0t3EO2c0qErVVODgoUCKZDfPbgjZY98348a7A-qKJGupCf38Cr2NqzSSPQdaVwA1KCCq2FL0KTknXDw1I4XbjN29GDvxn547eKIfh6z-A9dFrGg</recordid><startdate>20190402</startdate><enddate>20190402</enddate><creator>Echeverría, Coro</creator><creator>Aragón-Gutiérrez, Alejandro</creator><creator>Fernández-García, Marta</creator><creator>Muñoz-Bonilla, Alexandra</creator><creator>López, Daniel</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6386-5798</orcidid></search><sort><creationdate>20190402</creationdate><title>Thermoresponsive Poly( N -Isopropylacrylamide- co -Dimethylaminoethyl Methacrylate) Microgel Aqueous Dispersions with Potential Antimicrobial Properties</title><author>Echeverría, Coro ; Aragón-Gutiérrez, Alejandro ; Fernández-García, Marta ; Muñoz-Bonilla, Alexandra ; López, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-3306e26d319bf2065ebd35c6860ecd72993e18d120c5217264322494cb2929de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alkylation</topic><topic>Antibiotics</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Chemical precipitation</topic><topic>Copolymerization</topic><topic>Design</topic><topic>Drug delivery systems</topic><topic>Emulsion polymerization</topic><topic>Isopropylacrylamide</topic><topic>Microgels</topic><topic>Microorganisms</topic><topic>Molecular weight</topic><topic>Monomers</topic><topic>Nanoparticles</topic><topic>Peptides</topic><topic>Physical properties</topic><topic>Polymerization</topic><topic>Polymers</topic><topic>Surface charge</topic><topic>Viscoelasticity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Echeverría, Coro</creatorcontrib><creatorcontrib>Aragón-Gutiérrez, Alejandro</creatorcontrib><creatorcontrib>Fernández-García, Marta</creatorcontrib><creatorcontrib>Muñoz-Bonilla, Alexandra</creatorcontrib><creatorcontrib>López, Daniel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Echeverría, Coro</au><au>Aragón-Gutiérrez, Alejandro</au><au>Fernández-García, Marta</au><au>Muñoz-Bonilla, Alexandra</au><au>López, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thermoresponsive Poly( N -Isopropylacrylamide- co -Dimethylaminoethyl Methacrylate) Microgel Aqueous Dispersions with Potential Antimicrobial Properties</atitle><jtitle>Polymers</jtitle><addtitle>Polymers (Basel)</addtitle><date>2019-04-02</date><risdate>2019</risdate><volume>11</volume><issue>4</issue><spage>606</spage><pages>606-</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>The work herein describes the preparation of thermoresponsive microgels with potential antimicrobial properties. Most of the work performed so far regarding microgels with antimicrobial activity, deals with the ability of microgels to carry and release antibiotics or antimicrobial agents (antimicrobial peptides). The originality of this work lies in the possibility of developing intrinsic antimicrobial microgels by copolymerization of the well-known thermoresponsive monomer,
-isopropylacrylamide (NIPAM) with dimethylaminoethyl methacrylate (DMAEMA), a water-soluble monomer, to form microgels via precipitation polymerization (radical polymerization). Due to the presence of a tertiary amine in the DMAEMA comonomer, microgels can be modified by
-alkylation reaction with methyl and butyl iodide. This quaternization confers positive charges to the microgel surfaces and thus the potential antimicrobial activity. The effect of DMAEMA content and its quaternization with both, methyl and butyl iodide is evaluated in terms of thermal and surface charge properties, as well as in the microgel size and viscoelastic behavior. Finally, a preliminary study of the antimicrobial activity against different microorganisms is also performed in terms of minimum inhibitory concentration (MIC). From this study we determined that in contrast with butylated microgels, methylated ones show potential antimicrobial activity and good physical properties besides of maintaining microgel thermo-responsiveness.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30960590</pmid><doi>10.3390/polym11040606</doi><orcidid>https://orcid.org/0000-0001-6386-5798</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2073-4360 |
| ispartof | Polymers, 2019-04, Vol.11 (4), p.606 |
| issn | 2073-4360 2073-4360 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6523738 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alkylation Antibiotics Antiinfectives and antibacterials Antimicrobial agents Chemical precipitation Copolymerization Design Drug delivery systems Emulsion polymerization Isopropylacrylamide Microgels Microorganisms Molecular weight Monomers Nanoparticles Peptides Physical properties Polymerization Polymers Surface charge Viscoelasticity |
| title | Thermoresponsive Poly( N -Isopropylacrylamide- co -Dimethylaminoethyl Methacrylate) Microgel Aqueous Dispersions with Potential Antimicrobial Properties |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T07%3A21%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Thermoresponsive%20Poly(%20N%20-Isopropylacrylamide-%20co%20-Dimethylaminoethyl%20Methacrylate)%20Microgel%20Aqueous%20Dispersions%20with%20Potential%20Antimicrobial%20Properties&rft.jtitle=Polymers&rft.au=Echeverr%C3%ADa,%20Coro&rft.date=2019-04-02&rft.volume=11&rft.issue=4&rft.spage=606&rft.pages=606-&rft.issn=2073-4360&rft.eissn=2073-4360&rft_id=info:doi/10.3390/polym11040606&rft_dat=%3Cproquest_pubme%3E2557228232%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2557228232&rft_id=info:pmid/30960590&rfr_iscdi=true |