Vorapaxar stabilizes permeability of the endothelial barrier under cholesterol stimulation via the AKT/JNK and NF‑κB signaling pathways

Atherosclerosis (AS) is an inflammatory disease that occurs in the arterial wall and is characterized by progressive lipid accumulation within the intima of large arteries, leading to the dysfunction of endothelial cells and further destruction of the endothelial barrier and vascular tone. Arterial...

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Veröffentlicht in:	Molecular medicine reports 2019-06, Vol.19 (6), p.5291-5300
Hauptverfasser:	Pang, Jianliang, Hu, Peiyang, Wang, Junwei, Jiang, Jinsong, Lai, Jifu
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Arteries Arteriosclerosis Blood clots Blood platelets Calcium (intracellular) Calcium - metabolism Cell cycle Cell Line Cell proliferation Cell Survival - drug effects Cholesterol Cholesterol - pharmacology Connexin 43 Connexin 43 - metabolism Cytokines - genetics Cytokines - metabolism DNA damage Drugs Endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Experiments Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - metabolism Growth factors Homeostasis Humans Inflammatory diseases Intracellular signalling JNK Mitogen-Activated Protein Kinases - metabolism Kinases Lactones - pharmacology Lipids NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric Oxide - metabolism Permeability Permeability - drug effects Phosphorylation Physiology Platelets Proteins Proto-Oncogene Proteins c-akt - metabolism Pyridines - pharmacology Secretion Signal transduction Signal Transduction - drug effects Smooth muscle Thrombosis Up-Regulation - drug effects
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