Structural and free energy landscape of novel mutations in ribosomal protein S1 (rpsA) associated with pyrazinamide resistance

Resistance to key first-line drugs is a major hurdle to achieve the global end tuberculosis (TB) targets. A prodrug, pyrazinamide (PZA) is the only drug, effective in latent TB, recommended in drug resistance and susceptible Mycobacterium tuberculosis (MTB) isolates. The prodrug conversion into acti...

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Veröffentlicht in:	Scientific reports 2019-05, Vol.9 (1), p.7482-7482, Article 7482
Hauptverfasser:	Khan, Muhammad Tahir, Khan, Abbas, Rehman, Ashfaq Ur, Wang, Yanjie, Akhtar, Khalid, Malik, Shaukat Iqbal, Wei, Dong-Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 45/23 45/70 631/114/2397 692/699/255/1318 Amidohydrolases - chemistry Amidohydrolases - genetics Amidohydrolases - metabolism Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Binding Sites Drug resistance Drug Resistance, Bacterial Free energy Genes Humanities and Social Sciences Molecular Docking Simulation multidisciplinary Mutation PncA gene Protein Binding Protein folding Proteins Pyrazinamide Pyrazinamide - chemistry Pyrazinamide - pharmacology Ribosomal protein S1 Ribosomal Proteins - chemistry Ribosomal Proteins - genetics Ribosomal Proteins - metabolism Science Science (multidisciplinary) Tuberculosis
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