Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers

We hypothesized that candidate dependencies for which there are small molecules that are either approved or in advanced development for a nononcology indication may represent potential therapeutic targets. To test this hypothesis, we performed genome-scale loss-of-function screens in hundreds of can...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-05, Vol.79 (10), p.2564-2579
Hauptverfasser:	Price, Colles, Gill, Stanley, Ho, Zandra V, Davidson, Shawn M, Merkel, Erin, McFarland, James M, Leung, Lisa, Tang, Andrew, Kost-Alimova, Maria, Tsherniak, Aviad, Jonas, Oliver, Vazquez, Francisca, Hahn, William C
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor CRISPR-Cas Systems Female Genome-Wide Association Study Humans Hypoxia-Inducible Factor-Proline Dioxygenases - genetics Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology RNA Interference
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