Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis

Most forms of chronic kidney disease culminate in renal fibrosis that heralds organ failure. In contrast to the protective effects of globally blocking type 1 angiotensin (AT1) receptors throughout the body, activating AT1 receptors directly on immune cells may serve protective functions. However, t...

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Veröffentlicht in:	The American journal of pathology 2019-05, Vol.189 (5), p.981-988
Hauptverfasser:	Wen, Yi, Rudemiller, Nathan P., Zhang, Jiandong, Jeffs, Alexander D., Griffiths, Robert, Lu, Xiaohan, Ren, Jiafa, Privratsky, Jamie, Crowley, Steven D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Disease Models, Animal Fibrosis - immunology Fibrosis - metabolism Fibrosis - pathology Fibrosis - prevention & control Inflammation - immunology Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Kidney Diseases - immunology Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - prevention & control Male Mice Mice, Knockout Receptor, Angiotensin, Type 1 - physiology T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology
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