Dynamic salience processing in paraventricular thalamus gates associative learning
The salience of behaviorally relevant stimuli is dynamic and influenced by internal state and external environment. Monitoring such changes is critical for effective learning and flexible behavior, but the neuronal substrate for tracking the dynamics of stimulus salience is obscure. We found that ne...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2018-10, Vol.362 (6413), p.423-429 |
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| creator | Zhu, Yingjie Nachtrab, Gregory Keyes, Piper C Allen, William E Luo, Liqun Chen, Xiaoke |
| description | The salience of behaviorally relevant stimuli is dynamic and influenced by internal state and external environment. Monitoring such changes is critical for effective learning and flexible behavior, but the neuronal substrate for tracking the dynamics of stimulus salience is obscure. We found that neurons in the paraventricular thalamus (PVT) are robustly activated by a variety of behaviorally relevant events, including novel ("unfamiliar") stimuli, reinforcing stimuli and their predicting cues, as well as omission of the expected reward. PVT responses are scaled with stimulus intensity and modulated by changes in homeostatic state or behavioral context. Inhibition of the PVT responses suppresses appetitive or aversive associative learning and reward extinction. Our findings demonstrate that the PVT gates associative learning by providing a dynamic representation of stimulus salience. |
| doi_str_mv | 10.1126/science.aat0481 |
| format | Article |
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Monitoring such changes is critical for effective learning and flexible behavior, but the neuronal substrate for tracking the dynamics of stimulus salience is obscure. We found that neurons in the paraventricular thalamus (PVT) are robustly activated by a variety of behaviorally relevant events, including novel ("unfamiliar") stimuli, reinforcing stimuli and their predicting cues, as well as omission of the expected reward. PVT responses are scaled with stimulus intensity and modulated by changes in homeostatic state or behavioral context. Inhibition of the PVT responses suppresses appetitive or aversive associative learning and reward extinction. Our findings demonstrate that the PVT gates associative learning by providing a dynamic representation of stimulus salience.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.aat0481</identifier><identifier>PMID: 30361366</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Animals ; Associative learning ; Brain stem ; Cerebral cortex ; Conditioning, Classical - physiology ; Cues ; Environmental monitoring ; Forebrain ; Gates ; Hypothalamus ; Inhibition (psychology) ; Learning ; Male ; Mice ; Mice, Inbred C57BL ; Midline Thalamic Nuclei - physiology ; Neurons ; Neurons - physiology ; Reinforcement ; Reward ; Salience ; Sensory stimuli ; Sleep ; Sleep and wakefulness ; Somatosensory cortex ; Stimuli ; Substrates ; Thalamus ; Wakefulness</subject><ispartof>Science (American Association for the Advancement of Science), 2018-10, Vol.362 (6413), p.423-429</ispartof><rights>Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. 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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Associative learning Brain stem Cerebral cortex Conditioning, Classical - physiology Cues Environmental monitoring Forebrain Gates Hypothalamus Inhibition (psychology) Learning Male Mice Mice, Inbred C57BL Midline Thalamic Nuclei - physiology Neurons Neurons - physiology Reinforcement Reward Salience Sensory stimuli Sleep Sleep and wakefulness Somatosensory cortex Stimuli Substrates Thalamus Wakefulness |
| title | Dynamic salience processing in paraventricular thalamus gates associative learning |
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