Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell m...
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| Veröffentlicht in: | Chemical science (Cambridge) 2019-05, Vol.10 (18), p.4847-4853 |
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| container_title | Chemical science (Cambridge) |
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| creator | Lu, Guihong Lv, Chengliang Bao, Weier Li, Feng Zhang, Fan Zhang, Lijun Wang, Shuang Gao, Xiaoyong Zhao, Dongxu Wei, Wei Xie, Hai-Yan |
| description | Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (∼55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy. |
| doi_str_mv | 10.1039/c9sc00324j |
| format | Article |
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To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (∼55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy.</description><identifier>ISSN: 2041-6520</identifier><identifier>EISSN: 2041-6539</identifier><identifier>DOI: 10.1039/c9sc00324j</identifier><identifier>PMID: 31183034</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Camouflage ; Cell membranes ; Chemistry ; Nanomaterials ; Nanoparticles ; Optimization ; Photodynamic therapy ; Side effects ; Stability ; Tumors</subject><ispartof>Chemical science (Cambridge), 2019-05, Vol.10 (18), p.4847-4853</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><rights>This journal is © The Royal Society of Chemistry 2019 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-be5601c0dbb136d200c4788e89e07056086ea59f4229a5b81e62038ec21849ba3</citedby><cites>FETCH-LOGICAL-c406t-be5601c0dbb136d200c4788e89e07056086ea59f4229a5b81e62038ec21849ba3</cites><orcidid>0000-0002-6244-3187 ; 0000-0002-6330-7929</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520929/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520929/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31183034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Guihong</creatorcontrib><creatorcontrib>Lv, Chengliang</creatorcontrib><creatorcontrib>Bao, Weier</creatorcontrib><creatorcontrib>Li, Feng</creatorcontrib><creatorcontrib>Zhang, Fan</creatorcontrib><creatorcontrib>Zhang, Lijun</creatorcontrib><creatorcontrib>Wang, Shuang</creatorcontrib><creatorcontrib>Gao, Xiaoyong</creatorcontrib><creatorcontrib>Zhao, Dongxu</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Xie, Hai-Yan</creatorcontrib><title>Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics</title><title>Chemical science (Cambridge)</title><addtitle>Chem Sci</addtitle><description>Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (∼55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy.</description><subject>Camouflage</subject><subject>Cell membranes</subject><subject>Chemistry</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Optimization</subject><subject>Photodynamic therapy</subject><subject>Side effects</subject><subject>Stability</subject><subject>Tumors</subject><issn>2041-6520</issn><issn>2041-6539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkU1r3DAQhkVoyC5JLvkBxdBLKbgZfdhrXQphadqGQA5JzkKWx2sttrSV5Cz77-PNx9JmDjMD8_AyMy8hFxS-U-Dy0shoADgT6yMyZyBoXhZcfjr0DGbkPMY1TME5LdjihMw4pRUHLubEXLlkB-_QYba1qcvS1uc-NBhi7tt80Ctn09hgZodN8E_YZDHp2vY27bLWh6yzqy7fYJj6QTuDmdnnkKUOg3Y-JmviGTludR_x_K2eksfrnw_L3_nt3a8_y6vb3AgoU15jUQI10NQ15WXDAIxYVBVWEmEB06wqUReyFYxJXdQVxZIBr9AwWglZa35KfrzqbsZ6wMagS0H3ahPsoMNOeW3V_xNnO7XyT2r_JcnkJPD1TSD4vyPGpAYbDfa9dujHqBgXAIKXEib0ywd07cfgpvMUY4yWfCFpMVHfXikTfIwB28MyFNTePrWU98sX-24m-PO_6x_Qd7P4M-j6ln0</recordid><startdate>20190514</startdate><enddate>20190514</enddate><creator>Lu, Guihong</creator><creator>Lv, Chengliang</creator><creator>Bao, Weier</creator><creator>Li, Feng</creator><creator>Zhang, Fan</creator><creator>Zhang, Lijun</creator><creator>Wang, Shuang</creator><creator>Gao, Xiaoyong</creator><creator>Zhao, Dongxu</creator><creator>Wei, Wei</creator><creator>Xie, Hai-Yan</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6244-3187</orcidid><orcidid>https://orcid.org/0000-0002-6330-7929</orcidid></search><sort><creationdate>20190514</creationdate><title>Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics</title><author>Lu, Guihong ; Lv, Chengliang ; Bao, Weier ; Li, Feng ; Zhang, Fan ; Zhang, Lijun ; Wang, Shuang ; Gao, Xiaoyong ; Zhao, Dongxu ; Wei, Wei ; Xie, Hai-Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-be5601c0dbb136d200c4788e89e07056086ea59f4229a5b81e62038ec21849ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Camouflage</topic><topic>Cell membranes</topic><topic>Chemistry</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Optimization</topic><topic>Photodynamic therapy</topic><topic>Side effects</topic><topic>Stability</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Guihong</creatorcontrib><creatorcontrib>Lv, Chengliang</creatorcontrib><creatorcontrib>Bao, Weier</creatorcontrib><creatorcontrib>Li, Feng</creatorcontrib><creatorcontrib>Zhang, Fan</creatorcontrib><creatorcontrib>Zhang, Lijun</creatorcontrib><creatorcontrib>Wang, Shuang</creatorcontrib><creatorcontrib>Gao, Xiaoyong</creatorcontrib><creatorcontrib>Zhao, Dongxu</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Xie, Hai-Yan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical science (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Guihong</au><au>Lv, Chengliang</au><au>Bao, Weier</au><au>Li, Feng</au><au>Zhang, Fan</au><au>Zhang, Lijun</au><au>Wang, Shuang</au><au>Gao, Xiaoyong</au><au>Zhao, Dongxu</au><au>Wei, Wei</au><au>Xie, Hai-Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics</atitle><jtitle>Chemical science (Cambridge)</jtitle><addtitle>Chem Sci</addtitle><date>2019-05-14</date><risdate>2019</risdate><volume>10</volume><issue>18</issue><spage>4847</spage><epage>4853</epage><pages>4847-4853</pages><issn>2041-6520</issn><eissn>2041-6539</eissn><abstract>Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (∼55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>31183034</pmid><doi>10.1039/c9sc00324j</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6244-3187</orcidid><orcidid>https://orcid.org/0000-0002-6330-7929</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Camouflage Cell membranes Chemistry Nanomaterials Nanoparticles Optimization Photodynamic therapy Side effects Stability Tumors |
| title | Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics |
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