HNRNPL Restrains miR-155 Targeting of BUB1 to Stabilize Aberrant Karyotypes of Transformed Cells in Chronic Lymphocytic Leukemia

Aneuploidy and overexpression of ( ) characterize most solid and hematological malignancies. We recently demonstrated that sustains aneuploidy at early stages of in vitro cellular transformation. During in vitro transformation of normal human fibroblast, upregulation of downregulates spindle checkpo...

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Veröffentlicht in:	Cancers 2019-04, Vol.11 (4), p.575
Hauptverfasser:	Pagotto, Sara, Veronese, Angelo, Soranno, Alessandra, Balatti, Veronica, Ramassone, Alice, Guanciali-Franchi, Paolo E, Palka, Giandomenico, Innocenti, Idanna, Autore, Francesco, Rassenti, Laura Z, Kipps, Thomas J, Mariani-Costantini, Renato, Laurenti, Luca, Croce, Carlo M, Visone, Rosa
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Aneuploidy Benzimidazoles BUB1 gene Chromosomes Chronic lymphocytic leukemia Cloning Experiments Genetic transformation Hypotheses Karyotypes Kinases Leukemia Lymphatic leukemia Metaphase miRNA Molecular modelling Protein expression Protein-serine/threonine kinase Proteins Transformed cells Tumor cells
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