EGFR and HER3 expression in circulating tumor cells and tumor tissue from non-small cell lung cancer patients

Although clinically relevant, the detection rates of EpCAM positive CTCs in non-small cell lung cancer (NSCLC) are surprisingly low. To find new clinically informative markers for CTC detection in NSCLC, the expression of EGFR and HER3 was first analyzed in NSCLC tissue (n = 148). A positive EGFR an...

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Veröffentlicht in:	Scientific reports 2019-05, Vol.9 (1), p.7406-7406, Article 7406
Hauptverfasser:	Scharpenseel, Heather, Hanssen, Annkathrin, Loges, Sonja, Mohme, Malte, Bernreuther, Christian, Peine, Sven, Lamszus, Katrin, Goy, Yvonne, Petersen, Cordula, Westphal, Manfred, Glatzel, Markus, Riethdorf, Sabine, Pantel, Klaus, Wikman, Harriet
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/105 13/106 13/51 14 14/1 14/34 14/63 45/23 631/1647/2230 631/67/1612/1350 692/4028/67/1612/1350 Adult Aged Aged, 80 and over Biomarkers, Tumor Biopsy Brain Neoplasms - secondary Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology CD45 antigen Epidermal growth factor receptors ErbB protein ErbB Receptors - metabolism Female Gene Expression Regulation, Neoplastic Humanities and Social Sciences Humans Immunomagnetic Separation Keratin Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Metastases Metastasis Middle Aged multidisciplinary Neoplastic Cells, Circulating - metabolism Non-small cell lung carcinoma Receptor, ErbB-3 - metabolism Science Science (multidisciplinary) Subpopulations Tissue Array Analysis Tumor cells Tumors
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