Evaluation of a sequential enzyme immunoassay testing algorithm for Lyme disease demonstrates lack of test independence but high diagnostic specificity

To diagnose Lyme disease, a two-tier testing algorithm is used in which supplemental IgM and IgG immunoblots to detect antibody to Borrelia burgdorferi are reflexively performed if a first-tier assay, such as a whole-cell sonicate-based enzyme immunoassay (WCS EIA), is reactive. Recent data suggest...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2018-07, Vol.91 (3), p.217-219
Hauptverfasser:	Wormser, Gary P., Molins, Claudia R., Levin, Andrew, Lipsett, Susan C., Nigrovic, Lise E., Schriefer, Martin E., Branda, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Antibodies, Bacterial - blood Borrelia burgdorferi C6 Lyme test Humans Immunoenzyme Techniques - methods Immunoglobulin G - blood Immunoglobulin M - blood Lyme disease Lyme Disease - diagnosis Sensitivity and Specificity Test independence Two-tier serology
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