Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment
Abstract Recent research indicates the hippocampus may code the distance to the goal during navigation of newly learned environments. It is unclear however, whether this also pertains to highly familiar environments where extensive systems-level consolidation is thought to have transformed mnemonic...
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Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2019-06, Vol.29 (6), p.2748-2758 |
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container_title | Cerebral cortex (New York, N.Y. 1991) |
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creator | Patai, E Zita Javadi, Amir-Homayoun Ozubko, Jason D O’Callaghan, Andrew Ji, Shuman Robin, Jessica Grady, Cheryl Winocur, Gordon Rosenbaum, R Shayna Moscovitch, Morris Spiers, Hugo J |
description | Abstract
Recent research indicates the hippocampus may code the distance to the goal during navigation of newly learned environments. It is unclear however, whether this also pertains to highly familiar environments where extensive systems-level consolidation is thought to have transformed mnemonic representations. Here we recorded fMRI while University College London and Imperial College London students navigated virtual simulations of their own familiar campus (>2 years of exposure) and the other campus learned days before scanning. Posterior hippocampal activity tracked the distance to the goal in the newly learned campus, as well as in familiar environments when the future route contained many turns. By contrast retrosplenial cortex only tracked the distance to the goal in the familiar campus. All of these responses were abolished when participants were guided to their goal by external cues. These results open new avenues of research on navigation and consolidation of spatial information and underscore the notion that the hippocampus continues to play a role in navigation when detailed processing of the environment is needed for navigation. |
doi_str_mv | 10.1093/cercor/bhz044 |
format | Article |
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Recent research indicates the hippocampus may code the distance to the goal during navigation of newly learned environments. It is unclear however, whether this also pertains to highly familiar environments where extensive systems-level consolidation is thought to have transformed mnemonic representations. Here we recorded fMRI while University College London and Imperial College London students navigated virtual simulations of their own familiar campus (>2 years of exposure) and the other campus learned days before scanning. Posterior hippocampal activity tracked the distance to the goal in the newly learned campus, as well as in familiar environments when the future route contained many turns. By contrast retrosplenial cortex only tracked the distance to the goal in the familiar campus. All of these responses were abolished when participants were guided to their goal by external cues. These results open new avenues of research on navigation and consolidation of spatial information and underscore the notion that the hippocampus continues to play a role in navigation when detailed processing of the environment is needed for navigation.</description><identifier>ISSN: 1047-3211</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhz044</identifier><identifier>PMID: 30916744</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Original</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2019-06, Vol.29 (6), p.2748-2758</ispartof><rights>The Author(s) 2019. Published by Oxford University Press. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-d04b205db79a56e38b0f8f4d864f151eb8ebed285419fff1198a903a87cb044a3</citedby><cites>FETCH-LOGICAL-c420t-d04b205db79a56e38b0f8f4d864f151eb8ebed285419fff1198a903a87cb044a3</cites><orcidid>0000-0003-0569-6441 ; 0000-0003-2589-2239</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,1579,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30916744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patai, E Zita</creatorcontrib><creatorcontrib>Javadi, Amir-Homayoun</creatorcontrib><creatorcontrib>Ozubko, Jason D</creatorcontrib><creatorcontrib>O’Callaghan, Andrew</creatorcontrib><creatorcontrib>Ji, Shuman</creatorcontrib><creatorcontrib>Robin, Jessica</creatorcontrib><creatorcontrib>Grady, Cheryl</creatorcontrib><creatorcontrib>Winocur, Gordon</creatorcontrib><creatorcontrib>Rosenbaum, R Shayna</creatorcontrib><creatorcontrib>Moscovitch, Morris</creatorcontrib><creatorcontrib>Spiers, Hugo J</creatorcontrib><title>Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Abstract
Recent research indicates the hippocampus may code the distance to the goal during navigation of newly learned environments. It is unclear however, whether this also pertains to highly familiar environments where extensive systems-level consolidation is thought to have transformed mnemonic representations. Here we recorded fMRI while University College London and Imperial College London students navigated virtual simulations of their own familiar campus (>2 years of exposure) and the other campus learned days before scanning. Posterior hippocampal activity tracked the distance to the goal in the newly learned campus, as well as in familiar environments when the future route contained many turns. By contrast retrosplenial cortex only tracked the distance to the goal in the familiar campus. All of these responses were abolished when participants were guided to their goal by external cues. 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Recent research indicates the hippocampus may code the distance to the goal during navigation of newly learned environments. It is unclear however, whether this also pertains to highly familiar environments where extensive systems-level consolidation is thought to have transformed mnemonic representations. Here we recorded fMRI while University College London and Imperial College London students navigated virtual simulations of their own familiar campus (>2 years of exposure) and the other campus learned days before scanning. Posterior hippocampal activity tracked the distance to the goal in the newly learned campus, as well as in familiar environments when the future route contained many turns. By contrast retrosplenial cortex only tracked the distance to the goal in the familiar campus. All of these responses were abolished when participants were guided to their goal by external cues. These results open new avenues of research on navigation and consolidation of spatial information and underscore the notion that the hippocampus continues to play a role in navigation when detailed processing of the environment is needed for navigation.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>30916744</pmid><doi>10.1093/cercor/bhz044</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0569-6441</orcidid><orcidid>https://orcid.org/0000-0003-2589-2239</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Original |
title | Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment |
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