Local anaesthesia for endovascular repair of ruptured abdominal aortic aneurysm

Background Case series and a post hoc subgroup analysis of a large randomized trial have suggested a potential benefit in treating ruptured abdominal aortic aneurysms (rAAAs) using endovascular aneurysm repair (EVAR) with local anaesthesia (LA) rather than general anaesthesia (GA). The uptake and ou...

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Veröffentlicht in:British journal of surgery 2019-01, Vol.106 (1), p.74-81
Hauptverfasser: Mouton, R., Rogers, C. A., Harris, R. A., Hinchliffe, R. J.
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container_issue 1
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container_title British journal of surgery
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creator Mouton, R.
Rogers, C. A.
Harris, R. A.
Hinchliffe, R. J.
description Background Case series and a post hoc subgroup analysis of a large randomized trial have suggested a potential benefit in treating ruptured abdominal aortic aneurysms (rAAAs) using endovascular aneurysm repair (EVAR) with local anaesthesia (LA) rather than general anaesthesia (GA). The uptake and outcomes of LA in clinical practice remain unknown. Methods The UK National Vascular Registry was interrogated for patients presenting with rAAA managed with EVAR under different modes of anaesthesia between 1 January 2014 and 31 December 2016. The primary outcome was in‐hospital mortality. Secondary outcomes included: the number of centres performing EVAR under LA; the proportion of patients receiving this technique; duration of hospital stay; and postoperative complications. Results Some 3101 patients with rAAA were treated in 72 hospitals during the study: 2306 underwent on open procedure and 795 had EVAR (LA, 319; GA, 435; regional anaesthesia, 41). Overall, 56 of 72 hospitals (78 per cent) offered LA for EVAR of rAAA. Baseline characteristics and morphology were similar across the three EVAR subgroups. Patients who had surgery under LA had a lower in‐hospital mortality rate than patients who received GA (59 of 319 (18·5 per cent) versus 122 of 435 (28·0 per cent)), and this was unchanged after adjustment for factors known to influence survival (adjusted hazard ratio 0·62, 95 per cent c.i. 0·45 to 0·85; P = 0·003). Median hospital stay and postoperative morbidity from other complications were similar. Conclusion The use of LA for EVAR of rAAA has been adopted widely in the UK. Mortality rates appear lower than in patients undergoing EVAR with GA. Improves 30‐day survival
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A. ; Harris, R. A. ; Hinchliffe, R. J.</creator><creatorcontrib>Mouton, R. ; Rogers, C. A. ; Harris, R. A. ; Hinchliffe, R. J.</creatorcontrib><description>Background Case series and a post hoc subgroup analysis of a large randomized trial have suggested a potential benefit in treating ruptured abdominal aortic aneurysms (rAAAs) using endovascular aneurysm repair (EVAR) with local anaesthesia (LA) rather than general anaesthesia (GA). The uptake and outcomes of LA in clinical practice remain unknown. Methods The UK National Vascular Registry was interrogated for patients presenting with rAAA managed with EVAR under different modes of anaesthesia between 1 January 2014 and 31 December 2016. The primary outcome was in‐hospital mortality. Secondary outcomes included: the number of centres performing EVAR under LA; the proportion of patients receiving this technique; duration of hospital stay; and postoperative complications. Results Some 3101 patients with rAAA were treated in 72 hospitals during the study: 2306 underwent on open procedure and 795 had EVAR (LA, 319; GA, 435; regional anaesthesia, 41). Overall, 56 of 72 hospitals (78 per cent) offered LA for EVAR of rAAA. Baseline characteristics and morphology were similar across the three EVAR subgroups. Patients who had surgery under LA had a lower in‐hospital mortality rate than patients who received GA (59 of 319 (18·5 per cent) versus 122 of 435 (28·0 per cent)), and this was unchanged after adjustment for factors known to influence survival (adjusted hazard ratio 0·62, 95 per cent c.i. 0·45 to 0·85; P = 0·003). Median hospital stay and postoperative morbidity from other complications were similar. Conclusion The use of LA for EVAR of rAAA has been adopted widely in the UK. Mortality rates appear lower than in patients undergoing EVAR with GA. Improves 30‐day survival</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.10973</identifier><identifier>PMID: 30136715</identifier><language>eng</language><publisher>Chichester, UK: John Wiley &amp; Sons, Ltd</publisher><subject>Aged ; Anesthesia, Local - methods ; Anesthesia, Local - mortality ; Aneurysms ; Aortic Aneurysm, Abdominal - mortality ; Aortic Aneurysm, Abdominal - surgery ; Aortic aneurysms ; Aortic Rupture - mortality ; Aortic Rupture - surgery ; Endovascular Procedures - methods ; Endovascular Procedures - mortality ; Female ; Health risk assessment ; Humans ; Length of Stay - statistics &amp; numerical data ; Local anesthesia ; Male ; Mortality ; Original ; Postoperative Complications - etiology ; Postoperative Complications - mortality ; Treatment Outcome</subject><ispartof>British journal of surgery, 2019-01, Vol.106 (1), p.74-81</ispartof><rights>2018 The Authors. published by John Wiley &amp; Sons Ltd on behalf of BJS Society Ltd.</rights><rights>2018 The Authors. BJS published by John Wiley &amp; Sons Ltd on behalf of BJS Society Ltd.</rights><rights>Copyright © 2019 BJS Society Ltd. Published by John Wiley &amp; Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4093-11dfe2fe2394da2e462736c6accf1205fe2a2f9acebea0453d9c3910ea2c84393</citedby><orcidid>0000-0002-6370-0800</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.10973$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.10973$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30136715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mouton, R.</creatorcontrib><creatorcontrib>Rogers, C. A.</creatorcontrib><creatorcontrib>Harris, R. A.</creatorcontrib><creatorcontrib>Hinchliffe, R. J.</creatorcontrib><title>Local anaesthesia for endovascular repair of ruptured abdominal aortic aneurysm</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background Case series and a post hoc subgroup analysis of a large randomized trial have suggested a potential benefit in treating ruptured abdominal aortic aneurysms (rAAAs) using endovascular aneurysm repair (EVAR) with local anaesthesia (LA) rather than general anaesthesia (GA). The uptake and outcomes of LA in clinical practice remain unknown. Methods The UK National Vascular Registry was interrogated for patients presenting with rAAA managed with EVAR under different modes of anaesthesia between 1 January 2014 and 31 December 2016. The primary outcome was in‐hospital mortality. Secondary outcomes included: the number of centres performing EVAR under LA; the proportion of patients receiving this technique; duration of hospital stay; and postoperative complications. Results Some 3101 patients with rAAA were treated in 72 hospitals during the study: 2306 underwent on open procedure and 795 had EVAR (LA, 319; GA, 435; regional anaesthesia, 41). Overall, 56 of 72 hospitals (78 per cent) offered LA for EVAR of rAAA. Baseline characteristics and morphology were similar across the three EVAR subgroups. Patients who had surgery under LA had a lower in‐hospital mortality rate than patients who received GA (59 of 319 (18·5 per cent) versus 122 of 435 (28·0 per cent)), and this was unchanged after adjustment for factors known to influence survival (adjusted hazard ratio 0·62, 95 per cent c.i. 0·45 to 0·85; P = 0·003). Median hospital stay and postoperative morbidity from other complications were similar. Conclusion The use of LA for EVAR of rAAA has been adopted widely in the UK. Mortality rates appear lower than in patients undergoing EVAR with GA. 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A.</creator><creator>Harris, R. A.</creator><creator>Hinchliffe, R. J.</creator><general>John Wiley &amp; Sons, Ltd</general><general>Oxford University Press</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6370-0800</orcidid></search><sort><creationdate>201901</creationdate><title>Local anaesthesia for endovascular repair of ruptured abdominal aortic aneurysm</title><author>Mouton, R. ; Rogers, C. A. ; Harris, R. A. ; Hinchliffe, R. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4093-11dfe2fe2394da2e462736c6accf1205fe2a2f9acebea0453d9c3910ea2c84393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Anesthesia, Local - methods</topic><topic>Anesthesia, Local - mortality</topic><topic>Aneurysms</topic><topic>Aortic Aneurysm, Abdominal - mortality</topic><topic>Aortic Aneurysm, Abdominal - surgery</topic><topic>Aortic aneurysms</topic><topic>Aortic Rupture - mortality</topic><topic>Aortic Rupture - surgery</topic><topic>Endovascular Procedures - methods</topic><topic>Endovascular Procedures - mortality</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Length of Stay - statistics &amp; numerical data</topic><topic>Local anesthesia</topic><topic>Male</topic><topic>Mortality</topic><topic>Original</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - mortality</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mouton, R.</creatorcontrib><creatorcontrib>Rogers, C. A.</creatorcontrib><creatorcontrib>Harris, R. A.</creatorcontrib><creatorcontrib>Hinchliffe, R. J.</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mouton, R.</au><au>Rogers, C. A.</au><au>Harris, R. A.</au><au>Hinchliffe, R. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local anaesthesia for endovascular repair of ruptured abdominal aortic aneurysm</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>2019-01</date><risdate>2019</risdate><volume>106</volume><issue>1</issue><spage>74</spage><epage>81</epage><pages>74-81</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><abstract>Background Case series and a post hoc subgroup analysis of a large randomized trial have suggested a potential benefit in treating ruptured abdominal aortic aneurysms (rAAAs) using endovascular aneurysm repair (EVAR) with local anaesthesia (LA) rather than general anaesthesia (GA). The uptake and outcomes of LA in clinical practice remain unknown. Methods The UK National Vascular Registry was interrogated for patients presenting with rAAA managed with EVAR under different modes of anaesthesia between 1 January 2014 and 31 December 2016. The primary outcome was in‐hospital mortality. Secondary outcomes included: the number of centres performing EVAR under LA; the proportion of patients receiving this technique; duration of hospital stay; and postoperative complications. Results Some 3101 patients with rAAA were treated in 72 hospitals during the study: 2306 underwent on open procedure and 795 had EVAR (LA, 319; GA, 435; regional anaesthesia, 41). Overall, 56 of 72 hospitals (78 per cent) offered LA for EVAR of rAAA. Baseline characteristics and morphology were similar across the three EVAR subgroups. Patients who had surgery under LA had a lower in‐hospital mortality rate than patients who received GA (59 of 319 (18·5 per cent) versus 122 of 435 (28·0 per cent)), and this was unchanged after adjustment for factors known to influence survival (adjusted hazard ratio 0·62, 95 per cent c.i. 0·45 to 0·85; P = 0·003). Median hospital stay and postoperative morbidity from other complications were similar. Conclusion The use of LA for EVAR of rAAA has been adopted widely in the UK. Mortality rates appear lower than in patients undergoing EVAR with GA. Improves 30‐day survival</abstract><cop>Chichester, UK</cop><pub>John Wiley &amp; Sons, Ltd</pub><pmid>30136715</pmid><doi>10.1002/bjs.10973</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6370-0800</orcidid><oa>free_for_read</oa></addata></record>
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subjects Aged
Anesthesia, Local - methods
Anesthesia, Local - mortality
Aneurysms
Aortic Aneurysm, Abdominal - mortality
Aortic Aneurysm, Abdominal - surgery
Aortic aneurysms
Aortic Rupture - mortality
Aortic Rupture - surgery
Endovascular Procedures - methods
Endovascular Procedures - mortality
Female
Health risk assessment
Humans
Length of Stay - statistics & numerical data
Local anesthesia
Male
Mortality
Original
Postoperative Complications - etiology
Postoperative Complications - mortality
Treatment Outcome
title Local anaesthesia for endovascular repair of ruptured abdominal aortic aneurysm
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