Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases

Inflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independent studies have now demonstrated that the “apoptotic” caspase‐8 can cleave gasdermin D (GSDMD) leading to pyroptosis‐like cell death and IL‐1β release in murine macrop...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The EMBO journal 2019-05, Vol.38 (10), p.n/a
Hauptverfasser: Gram, Anna M, Booty, Lee M, Bryant, Clare E
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page n/a
container_issue 10
container_start_page
container_title The EMBO journal
container_volume 38
creator Gram, Anna M
Booty, Lee M
Bryant, Clare E
description Inflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independent studies have now demonstrated that the “apoptotic” caspase‐8 can cleave gasdermin D (GSDMD) leading to pyroptosis‐like cell death and IL‐1β release in murine macrophages (Orning et al , 2018; Sarhan et al , 2018; Chen et al , 2019). Orning et al and Chen/Demarco et al also show that the NLRP3 inflammasome is activated downstream of active caspase‐8, but they attribute this inflammasome activation to different pore‐forming proteins, GSDMD and pannexin‐1, respectively (Orning et al , 2018; Chen et al , 2019). Graphical Abstract While caspase‐8 is normally associated with apoptosis, recent studies show that it is also involved in pyroptosis, cleaving gasdermin D to trigger pyroptosis‐like cell death and IL‐1β release in macrophages.
doi_str_mv 10.15252/embj.2019102065
format Article
fullrecord <record><control><sourceid>proquest_C6C</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6517822</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2210230575</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5195-1e2c074b188f3b8a07351056c4a443900323dff623e94617546a2a573d18efa53</originalsourceid><addsrcrecordid>eNqFkUtvEzEUhS0Eomlhz6oaiQ2bKff6MfZUVSVIH4BaIfFYW87EkziaGQ_2pFV2_Qn8Rn5JHRJaWgmxugt_59xzfQh5hXCAggr61raTxQEFLBEoFOIJGSEvIKcgxVMyAlpgzlGVO2Q3xgUACCXxOdlhUCoFKEbky3ju-951s-z868nlyWFWmdibaH_d_FTZ3MRs4V1np9kwt9lgTZv5OutXwfeDjy4mqrVTZ4a1wVYZX5BntWmifbmde-T72em38Yf84vP5x_G7i7wSWIocLa1A8gkqVbOJMiCZQBBFxQ3nrARglE3ruqDMlrxAKXhhqBGSTVHZ2gi2R443vv1yklJUthuCaXQfXGvCSnvj9MOXzs31zF_pQqBUlCaDN1uD4H8sbRx062Jlm8Z01i-jpjT9KgMh17teP0IXfhm6dF6iKC-BlxITBRuqCj7GYOu7MAj6d2F6XZi-LyxJ9v8-4k7wp6EEHG2Aa9fY1X8N9enl-08P_HEjj0nZzWy4D_7PTLeMe7M8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2224904971</pqid></control><display><type>article</type><title>Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases</title><source>Springer Nature OA Free Journals</source><creator>Gram, Anna M ; Booty, Lee M ; Bryant, Clare E</creator><creatorcontrib>Gram, Anna M ; Booty, Lee M ; Bryant, Clare E</creatorcontrib><description>Inflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independent studies have now demonstrated that the “apoptotic” caspase‐8 can cleave gasdermin D (GSDMD) leading to pyroptosis‐like cell death and IL‐1β release in murine macrophages (Orning et al , 2018; Sarhan et al , 2018; Chen et al , 2019). Orning et al and Chen/Demarco et al also show that the NLRP3 inflammasome is activated downstream of active caspase‐8, but they attribute this inflammasome activation to different pore‐forming proteins, GSDMD and pannexin‐1, respectively (Orning et al , 2018; Chen et al , 2019). Graphical Abstract While caspase‐8 is normally associated with apoptosis, recent studies show that it is also involved in pyroptosis, cleaving gasdermin D to trigger pyroptosis‐like cell death and IL‐1β release in macrophages.</description><identifier>ISSN: 0261-4189</identifier><identifier>EISSN: 1460-2075</identifier><identifier>DOI: 10.15252/embj.2019102065</identifier><identifier>PMID: 30988015</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Apoptosis ; Caspase ; Caspase 1 ; Caspase 8 ; Caspases ; Cell death ; Cutting ; EMBO07 ; EMBO19 ; Inflammasomes ; Macrophages ; News &amp; Views ; NLR Family, Pyrin Domain-Containing 3 Protein ; Pyroptosis ; Views</subject><ispartof>The EMBO journal, 2019-05, Vol.38 (10), p.n/a</ispartof><rights>The Author(s) 2019</rights><rights>2019 The Authors</rights><rights>2019 EMBO</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5195-1e2c074b188f3b8a07351056c4a443900323dff623e94617546a2a573d18efa53</citedby><cites>FETCH-LOGICAL-c5195-1e2c074b188f3b8a07351056c4a443900323dff623e94617546a2a573d18efa53</cites><orcidid>0000-0002-2924-0038</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517822/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517822/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1416,1432,27922,27923,41118,42187,45572,45573,46407,46831,51574,53789,53791</link.rule.ids><linktorsrc>$$Uhttps://doi.org/10.15252/embj.2019102065$$EView_record_in_Springer_Nature$$FView_record_in_$$GSpringer_Nature</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30988015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gram, Anna M</creatorcontrib><creatorcontrib>Booty, Lee M</creatorcontrib><creatorcontrib>Bryant, Clare E</creatorcontrib><title>Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases</title><title>The EMBO journal</title><addtitle>EMBO J</addtitle><addtitle>EMBO J</addtitle><description>Inflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independent studies have now demonstrated that the “apoptotic” caspase‐8 can cleave gasdermin D (GSDMD) leading to pyroptosis‐like cell death and IL‐1β release in murine macrophages (Orning et al , 2018; Sarhan et al , 2018; Chen et al , 2019). Orning et al and Chen/Demarco et al also show that the NLRP3 inflammasome is activated downstream of active caspase‐8, but they attribute this inflammasome activation to different pore‐forming proteins, GSDMD and pannexin‐1, respectively (Orning et al , 2018; Chen et al , 2019). Graphical Abstract While caspase‐8 is normally associated with apoptosis, recent studies show that it is also involved in pyroptosis, cleaving gasdermin D to trigger pyroptosis‐like cell death and IL‐1β release in macrophages.</description><subject>Apoptosis</subject><subject>Caspase</subject><subject>Caspase 1</subject><subject>Caspase 8</subject><subject>Caspases</subject><subject>Cell death</subject><subject>Cutting</subject><subject>EMBO07</subject><subject>EMBO19</subject><subject>Inflammasomes</subject><subject>Macrophages</subject><subject>News &amp; Views</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein</subject><subject>Pyroptosis</subject><subject>Views</subject><issn>0261-4189</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhS0Eomlhz6oaiQ2bKff6MfZUVSVIH4BaIfFYW87EkziaGQ_2pFV2_Qn8Rn5JHRJaWgmxugt_59xzfQh5hXCAggr61raTxQEFLBEoFOIJGSEvIKcgxVMyAlpgzlGVO2Q3xgUACCXxOdlhUCoFKEbky3ju-951s-z868nlyWFWmdibaH_d_FTZ3MRs4V1np9kwt9lgTZv5OutXwfeDjy4mqrVTZ4a1wVYZX5BntWmifbmde-T72em38Yf84vP5x_G7i7wSWIocLa1A8gkqVbOJMiCZQBBFxQ3nrARglE3ruqDMlrxAKXhhqBGSTVHZ2gi2R443vv1yklJUthuCaXQfXGvCSnvj9MOXzs31zF_pQqBUlCaDN1uD4H8sbRx062Jlm8Z01i-jpjT9KgMh17teP0IXfhm6dF6iKC-BlxITBRuqCj7GYOu7MAj6d2F6XZi-LyxJ9v8-4k7wp6EEHG2Aa9fY1X8N9enl-08P_HEjj0nZzWy4D_7PTLeMe7M8</recordid><startdate>20190515</startdate><enddate>20190515</enddate><creator>Gram, Anna M</creator><creator>Booty, Lee M</creator><creator>Bryant, Clare E</creator><general>Nature Publishing Group UK</general><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2924-0038</orcidid></search><sort><creationdate>20190515</creationdate><title>Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases</title><author>Gram, Anna M ; Booty, Lee M ; Bryant, Clare E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5195-1e2c074b188f3b8a07351056c4a443900323dff623e94617546a2a573d18efa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Apoptosis</topic><topic>Caspase</topic><topic>Caspase 1</topic><topic>Caspase 8</topic><topic>Caspases</topic><topic>Cell death</topic><topic>Cutting</topic><topic>EMBO07</topic><topic>EMBO19</topic><topic>Inflammasomes</topic><topic>Macrophages</topic><topic>News &amp; Views</topic><topic>NLR Family, Pyrin Domain-Containing 3 Protein</topic><topic>Pyroptosis</topic><topic>Views</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gram, Anna M</creatorcontrib><creatorcontrib>Booty, Lee M</creatorcontrib><creatorcontrib>Bryant, Clare E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The EMBO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Gram, Anna M</au><au>Booty, Lee M</au><au>Bryant, Clare E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases</atitle><jtitle>The EMBO journal</jtitle><stitle>EMBO J</stitle><addtitle>EMBO J</addtitle><date>2019-05-15</date><risdate>2019</risdate><volume>38</volume><issue>10</issue><epage>n/a</epage><issn>0261-4189</issn><eissn>1460-2075</eissn><abstract>Inflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independent studies have now demonstrated that the “apoptotic” caspase‐8 can cleave gasdermin D (GSDMD) leading to pyroptosis‐like cell death and IL‐1β release in murine macrophages (Orning et al , 2018; Sarhan et al , 2018; Chen et al , 2019). Orning et al and Chen/Demarco et al also show that the NLRP3 inflammasome is activated downstream of active caspase‐8, but they attribute this inflammasome activation to different pore‐forming proteins, GSDMD and pannexin‐1, respectively (Orning et al , 2018; Chen et al , 2019). Graphical Abstract While caspase‐8 is normally associated with apoptosis, recent studies show that it is also involved in pyroptosis, cleaving gasdermin D to trigger pyroptosis‐like cell death and IL‐1β release in macrophages.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30988015</pmid><doi>10.15252/embj.2019102065</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-2924-0038</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier ISSN: 0261-4189
ispartof The EMBO journal, 2019-05, Vol.38 (10), p.n/a
issn 0261-4189
1460-2075
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6517822
source Springer Nature OA Free Journals
subjects Apoptosis
Caspase
Caspase 1
Caspase 8
Caspases
Cell death
Cutting
EMBO07
EMBO19
Inflammasomes
Macrophages
News & Views
NLR Family, Pyrin Domain-Containing 3 Protein
Pyroptosis
Views
title Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T15%3A16%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_C6C&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chopping%20GSDMD:%20caspase%E2%80%908%20has%20joined%20the%20team%20of%20pyroptosis%E2%80%90mediating%20caspases&rft.jtitle=The%20EMBO%20journal&rft.au=Gram,%20Anna%20M&rft.date=2019-05-15&rft.volume=38&rft.issue=10&rft.epage=n/a&rft.issn=0261-4189&rft.eissn=1460-2075&rft_id=info:doi/10.15252/embj.2019102065&rft_dat=%3Cproquest_C6C%3E2210230575%3C/proquest_C6C%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2224904971&rft_id=info:pmid/30988015&rfr_iscdi=true