DAF‐16 stabilizes the aging transcriptome and is activated in mid‐aged Caenorhabditis elegans to cope with internal stress

The roles and regulatory mechanisms of transcriptome changes during aging are unclear. It has been proposed that the transcriptome suffers decay during aging owing to age‐associated down‐regulation of transcription factors. In this study, we characterized the role of a transcription factor DAF‐16, w...

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Veröffentlicht in:	Aging cell 2019-06, Vol.18 (3), p.e12896-n/a
Hauptverfasser:	Li, Shang‐Tong, Zhao, Han‐Qing, Zhang, Pan, Liang, Chung‐Yi, Zhang, Yan‐Ping, Hsu, Ao‐Lin, Dong, Meng‐Qiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - metabolism Analysis Animals Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cellular stress response DAF‐16 DNA binding proteins Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene expression Gene regulation Genes Insulin Life span Nematodes Original Paper Original Papers proteostasis Sequence Analysis, RNA Stress management stress response Stress, Physiological Transcription factors transcriptional regulation Transcriptome
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