Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids
Cell lines and animal models have provided the foundation of cancer research for many years. However, human pluripotent stem cells (hPSCs) and organoids are increasingly enabling insights into tumor development, progression, and treatment. Here, we review recent studies using hPSCs to elucidate the...
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| Veröffentlicht in: | Cell stem cell 2019-01, Vol.24 (1), p.12-24 |
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| creator | Smith, Ryan C. Tabar, Viviane |
| description | Cell lines and animal models have provided the foundation of cancer research for many years. However, human pluripotent stem cells (hPSCs) and organoids are increasingly enabling insights into tumor development, progression, and treatment. Here, we review recent studies using hPSCs to elucidate the reciprocal roles played by genetic alterations and cell identity in cancer formation. We also review studies using human organoids as models that recapitulate both intra- and inter-tumoral heterogeneity to gain new insights into tumorigenesis and treatment responses. Finally, we highlight potential opportunities for cancer research using hPSC-derived organoids and genome editing in the future.
Smith and Tabar discuss how models of human pluripotent stem cells (hPSCs) and organoids provide insights into tumor development, progression, and treatment, as well as potential opportunities for cancer research using hPSC-derived organoids and genome editing. |
| doi_str_mv | 10.1016/j.stem.2018.11.012 |
| format | Article |
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Smith and Tabar discuss how models of human pluripotent stem cells (hPSCs) and organoids provide insights into tumor development, progression, and treatment, as well as potential opportunities for cancer research using hPSC-derived organoids and genome editing.</description><subject>Animals</subject><subject>cancer</subject><subject>Cell Differentiation</subject><subject>cell identity</subject><subject>cell-of-origin</subject><subject>differentiation</subject><subject>disease modeling</subject><subject>drug screening</subject><subject>genome editing</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Neoplasms - pathology</subject><subject>organoids</subject><subject>Organoids - cytology</subject><subject>pluripotent stem cells</subject><subject>Pluripotent Stem Cells - cytology</subject><subject>tumor heterogeneity</subject><issn>1934-5909</issn><issn>1875-9777</issn><issn>1875-9777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcFq3DAUFKGh2W77AzkUH3uxoydbkgUhUNw2CSwkkBR6E7Isb7XY0layF_L30XaTkFxy0tPTzLzRG4ROAReAgZ1tijiZsSAY6gKgwECO0AJqTnPBOf-QalFWORVYnKBPMW4wphww_4hOSkzrVNUL9KfxLk5h1pN160y5Lvth9OtWo5w2IWZz3N-u5lG57HaYg936ybgpu0sWssYMQ_zPvglr5bzt4md03Kshmi9P5xL9_vXzvrnKVzeX1833Va4pgSlnhKuuIkzQiuOeKUYryjnVvWi1AQFV2VPVVpqWbW_autc1IbRKfVyTWjBWLtHFQXc7t6PpdPIU1CC3wY4qPEivrHz74uxfufY7ySgwzMsk8O1JIPh_s4mTHG3U6UPKGT9HSRIMKKkESVBygOrgYwymfxkDWO4jkRu5j0TuI5EAMkWSSF9fG3yhPGeQAOcHgElr2lkTZNTWpK13Nhg9yc7b9_QfAdPKno4</recordid><startdate>20190103</startdate><enddate>20190103</enddate><creator>Smith, Ryan C.</creator><creator>Tabar, Viviane</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190103</creationdate><title>Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids</title><author>Smith, Ryan C. ; Tabar, Viviane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-627ad42695470f6a6545775cf9bce19143f5ab4c53bfeb8fc8225491408289663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>cancer</topic><topic>Cell Differentiation</topic><topic>cell identity</topic><topic>cell-of-origin</topic><topic>differentiation</topic><topic>disease modeling</topic><topic>drug screening</topic><topic>genome editing</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Neoplasms - pathology</topic><topic>organoids</topic><topic>Organoids - cytology</topic><topic>pluripotent stem cells</topic><topic>Pluripotent Stem Cells - cytology</topic><topic>tumor heterogeneity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Ryan C.</creatorcontrib><creatorcontrib>Tabar, Viviane</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell stem cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Ryan C.</au><au>Tabar, Viviane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids</atitle><jtitle>Cell stem cell</jtitle><addtitle>Cell Stem Cell</addtitle><date>2019-01-03</date><risdate>2019</risdate><volume>24</volume><issue>1</issue><spage>12</spage><epage>24</epage><pages>12-24</pages><issn>1934-5909</issn><issn>1875-9777</issn><eissn>1875-9777</eissn><abstract>Cell lines and animal models have provided the foundation of cancer research for many years. However, human pluripotent stem cells (hPSCs) and organoids are increasingly enabling insights into tumor development, progression, and treatment. Here, we review recent studies using hPSCs to elucidate the reciprocal roles played by genetic alterations and cell identity in cancer formation. We also review studies using human organoids as models that recapitulate both intra- and inter-tumoral heterogeneity to gain new insights into tumorigenesis and treatment responses. Finally, we highlight potential opportunities for cancer research using hPSC-derived organoids and genome editing in the future.
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| ispartof | Cell stem cell, 2019-01, Vol.24 (1), p.12-24 |
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| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals cancer Cell Differentiation cell identity cell-of-origin differentiation disease modeling drug screening genome editing Humans Models, Biological Neoplasms - pathology organoids Organoids - cytology pluripotent stem cells Pluripotent Stem Cells - cytology tumor heterogeneity |
| title | Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids |
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