RSK2-Mediated ELK3 Activation Enhances Cell Transformation and Breast Cancer Cell Growth by Regulation of c-fos Promoter Activity

Ribosomal S6 kinase 2 (RSK2), regulated by Ras/Raf/MEKs/ERKs, transmits upstream activation signals to downstream substrates including kinases and transcription and epigenetic factors. We observed that ELK members, including ELK1, 3, and 4, highly interacted with RSK2. We further observed that the R...

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Veröffentlicht in:	International journal of molecular sciences 2019-04, Vol.20 (8), p.1994
Hauptverfasser:	Yoo, Sun-Mi, Lee, Cheol-Jung, An, Hyun-Jung, Lee, Joo Young, Lee, Hye Suk, Kang, Han Chang, Cho, Sung-Jun, Kim, Seung-Min, Park, Juhee, Kim, Dae Joon, Cho, Yong-Yeon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Amino acids Angiogenesis Apoptosis Binding Bone marrow Breast cancer c-Fos protein Cancer Cell activation Cell adhesion & migration Cell growth Cell proliferation Cytoplasm Esophagus Extracellular signal-regulated kinase Gene expression Gene regulation Glucose metabolism Growth factors Histone H3 Hypoxia Kinases Liver Localization Metastases Metastasis Muscles Pharynx Phosphorylation Protein biosynthesis Protein synthesis Proteins Signal transduction Skin Trachea Transcription factors Transformations Umbilical cord Uterus Vascular endothelial growth factor Vascular tissue
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