Improvement of l-Leucine Production in Corynebacterium glutamicum by Altering the Redox Flux

The production of l-leucine was improved by the disruption of encoding transcriptional regulator and overexpression of the key genes ( ) of the l-leucine biosynthesis pathway in XQ-9. In order to improve l-leucine production, we rationally engineered to enhance l-leucine production, by improving the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2019-04, Vol.20 (8), p.2020
Hauptverfasser:	Wang, Ying-Yu, Zhang, Feng, Xu, Jian-Zhong, Zhang, Wei-Guo, Chen, Xiu-Lai, Liu, Li-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid substitution Amino acids Animal feed Attenuation Bacterial Proteins - genetics Bacterial Proteins - metabolism Biosynthesis Biosynthetic Pathways Chain branching Corynebacterium glutamicum Corynebacterium glutamicum - genetics Corynebacterium glutamicum - metabolism Cosmetics Dehydrogenases Enzymes Fermentation Flavor Food additives Genes Glutamate Dehydrogenase (NADP+) - genetics Glutamate Dehydrogenase (NADP+) - metabolism Glutamic acid Homeostasis Ketol-Acid Reductoisomerase - genetics Ketol-Acid Reductoisomerase - metabolism Leucine Leucine - genetics Leucine - metabolism Leucine Dehydrogenase - genetics Leucine Dehydrogenase - metabolism Liver diseases Lysine Metabolic Engineering - methods Metabolism Mutagenesis Mutants NADH Nutritional status Oxidation-Reduction Production capacity Protein biosynthesis Protein synthesis Site-directed mutagenesis Transcription
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!