Inhalation of gas metal arc–stainless steel welding fume promotes lung tumorigenesis in A/J mice

Epidemiologic studies suggest an increased risk of lung cancer with exposure to welding fumes, but controlled animal studies are needed to support this association. Oropharyngeal aspiration of collected “aged” gas metal arc–stainless steel (GMA–SS) welding fume has been shown by our laboratory to pr...

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Veröffentlicht in:	Archives of toxicology 2017-08, Vol.91 (8), p.2953-2962
Hauptverfasser:	Falcone, Lauryn M., Erdely, Aaron, Meighan, Terence G., Battelli, Lori A., Salmen, Rebecca, McKinney, Walter, Stone, Samuel, Cumpston, Amy, Cumpston, Jared, Andrews, Ronnee N., Kashon, Michael, Antonini, James M., Zeidler-Erdely, Patti C.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Methylcholanthrene Administration, Inhalation Aerosols Air Pollutants, Occupational - toxicity Animals Arc welding Biomedical and Life Sciences Biomedicine Cancer Corn Corn oil Disease Models, Animal Environmental Health Epidemiology Exposure Fumes Genotoxicity and Carcinogenicity Group dynamics Health risks In vivo methods and tests Inhalation Inhalation Exposure - adverse effects Lung cancer Lung Neoplasms - chemically induced Lung Neoplasms - pathology Lung nodules Male Metals Methylcholanthrene - administration & dosage Mice Mice, Inbred Strains Natural gas Nodules Occupational Diseases - etiology Occupational Diseases - pathology Occupational exposure Occupational Exposure - adverse effects Occupational Medicine/Industrial Medicine Oil Pharmacology/Toxicology Pollutant deposition Promotion Respiration Risk Rodents Stainless steel Stainless Steel - toxicity Stainless steels Tumorigenesis Vegetable oils Welding Welding fumes Welding machines
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