$Impaired Renal Function May Not Negate the Efficacy of Tolvaptan in the Treatment of Cirrhotic Patients with Refractory Ascites$

Impaired Renal Function May Not Negate the Efficacy of Tolvaptan in the Treatment of Cirrhotic Patients with Refractory Ascites

Background and Objective Tolvaptan, an oral vasopressin V2 receptor antagonist, has been widely used for the treatment of patients with cirrhosis and ascites. However, its efficacy in patients with renal dysfunction remains unknown. The objective of this study was to investigate the efficacy and saf...

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Veröffentlicht in:	Clinical drug investigation 2019-01, Vol.39 (1), p.45-54
Hauptverfasser:	Arase, Yoshitaka, Kagawa, Tatehiro, Tsuruya, Kota, Sato, Hirohiko, Teramura, Erika, Anzai, Kazuya, Hirose, Shunji, Deguchi, Ryuzo, Shiraishi, Koichi, Mine, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antidiuretic Hormone Receptor Antagonists - therapeutic use Ascites - drug therapy Diabetes Diuretics Edema Female Glomerular Filtration Rate Heart failure Humans Internal Medicine Kidney diseases Liver cancer Liver cirrhosis Liver Cirrhosis - drug therapy Male Medical prognosis Medicine Medicine & Public Health Middle Aged Original Original Research Article Patients Pharmacology/Toxicology Pharmacotherapy Renal Insufficiency, Chronic - physiopathology Retrospective Studies Sodium Studies Tolvaptan - therapeutic use Urine
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