Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs

Endothelial cells have multifaceted interactions with the immune system, both as initiators and targets of immune responses. In vivo , apoptotic endothelial cells release two types of extracellular vesicles upon caspase-3 activation: apoptotic bodies and exosome-like nanovesicles (ApoExos). Only Apo...

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Veröffentlicht in:	Scientific reports 2019-05, Vol.9 (1), p.7203-7203, Article 7203
Hauptverfasser:	Hardy, Marie-Pierre, Audemard, Éric, Migneault, Francis, Feghaly, Albert, Brochu, Sylvie, Gendron, Patrick, Boilard, Éric, Major, François, Dieudé, Mélanie, Hébert, Marie-Josée, Perreault, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	38/91 631/250/262/2106 631/337/2019 631/45/500 631/553/1833 Apoptosis Autoimmunity Caspase Caspase-3 DEAD Box Protein 58 - metabolism Endothelial cells Extracellular vesicles Extracellular Vesicles - genetics Gene Expression Profiling - methods Human Umbilical Vein Endothelial Cells - chemistry Human Umbilical Vein Endothelial Cells - cytology Humanities and Social Sciences Humans Immune response Immune system Immunogenicity Immunostimulation Innate immunity multidisciplinary Nitric oxide Protein structure Receptors, Immunologic RNA - genetics RNA - immunology RNA Editing rRNA Science Science (multidisciplinary) Secondary structure Sequence Analysis, RNA Toll-Like Receptors - metabolism
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