Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury

Axonal degeneration occurs in various neurological diseases and traumatic nerve injury, and axonal regeneration is restricted by inhibitory factors in the central nervous system. Cyclin-dependent kinase 5 and glycogen synthase kinase 3β (GSK3β) are activated by one of those inhibitors, and collapsin...

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Veröffentlicht in:	Scientific reports 2019-05, Vol.9 (1), p.7188-7188, Article 7188
Hauptverfasser:	Kondo, Shunsuke, Takahashi, Kazuya, Kinoshita, Yuki, Nagai, Jun, Wakatsuki, Shuji, Araki, Toshiyuki, Goshima, Yoshio, Ohshima, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 42/34 631/337/458/1733 631/378/1687 64/110 Animals Axons Central nervous system Collapsin response mediator protein 2 Cyclin-dependent kinase Cyclin-dependent kinase 5 Cyclin-dependent kinases Depolymerization Disease Models, Animal Ganglia Gene Knock-In Techniques Glycogen Glycogen synthase kinase 3 Humanities and Social Sciences Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Kinases Male Mediator protein Mice Microtubules multidisciplinary Nerve Crush Nerve Regeneration Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurodegeneration Neurological diseases Optic nerve Optic Nerve Injuries - genetics Optic Nerve Injuries - metabolism Optic Nerve Injuries - therapy Phosphorylation Polymerization Regeneration Retina Science Science (multidisciplinary) Serine Serine - metabolism Spinal cord injuries
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