Genome mining and biosynthesis of kitacinnamycins as a STING activator

Cinnamoyl-containing nonribosomal peptides (CCNPs) are a small group of secondary metabolites with potent biological activities produced by actinobacteria. Two remarkable features in the biosynthesis of CCNPs include the nonribosomal peptide synthases (NRPSs) for assembly of the depsipeptide backbon...

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Veröffentlicht in:	Chemical science (Cambridge) 2019-05, Vol.10 (18), p.4839-4846
Hauptverfasser:	Shi, Jing, Liu, Cheng Li, Zhang, Bo, Guo, Wen Jie, Zhu, Jiapeng, Chang, Chin-Yuan, Zhao, Er Juan, Jiao, Rui Hua, Tan, Ren Xiang, Ge, Hui Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Assembly Backbone Biosynthesis Chemistry Crystallography Genomes Glycopeptides Interferon Metabolites Natural products Peptides Proteins Stimulators Substrates Sugar
Online-Zugang:	Volltext
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