β-Arrestins Regulate Stem Cell-Like Phenotype and Response to Chemotherapy in Bladder Cancer

β-Arrestins are classic attenuators of G-protein-coupled receptor signaling. However, they have multiple roles in cellular physiology, including carcinogenesis. This work shows for the first time that β-arrestins have prognostic significance for predicting metastasis and response to chemotherapy in...

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Veröffentlicht in:	Molecular cancer therapeutics 2019-04, Vol.18 (4), p.801-811
Hauptverfasser:	Kallifatidis, Georgios, Smith, Diandra K, Morera, Daley S, Gao, Jie, Hennig, Martin J, Hoy, James J, Pearce, Richard F, Dabke, Isha R, Li, Jiemin, Merseburger, Axel S, Kuczyk, Markus A, Lokeshwar, Vinata B, Lokeshwar, Bal L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use beta-Arrestin 1 - genetics beta-Arrestin 1 - metabolism beta-Arrestin 2 - genetics beta-Arrestin 2 - metabolism Cell Line, Tumor Cisplatin - administration & dosage Cisplatin - pharmacology Cisplatin - therapeutic use Cohort Studies Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxycytidine - therapeutic use Drug Resistance, Neoplasm - genetics Female Humans Male Mice Mice, Nude Phenotype Prognosis Stem Cells - drug effects Stem Cells - metabolism Transfection Tumor Burden - drug effects Urinary Bladder Neoplasms - drug therapy Xenograft Model Antitumor Assays
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