Symptom trajectories in patients with panic disorder in a primary care intervention: Results from a randomized controlled trial (PARADISE)

This analysis aims to identify and characterize symptom trajectories in primary care patients with panic disorder with/without agoraphobia (PD/AG) who participated in a primary care team based training involving elements of cognitive behavioural therapy (CBT). Growth Mixture Modeling was used to ide...

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Veröffentlicht in:Scientific reports 2019-05, Vol.9 (1), p.7170-7170, Article 7170
Hauptverfasser: Lukaschek, Karoline, Hiller, Thomas S., Schumacher, Ulrike, Teismann, Tobias, Breitbart, Jörg, Brettschneider, Christian, König, Hans-Helmut, Margraf, Jürgen, Gensichen, Jochen
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container_title Scientific reports
container_volume 9
creator Lukaschek, Karoline
Hiller, Thomas S.
Schumacher, Ulrike
Teismann, Tobias
Breitbart, Jörg
Brettschneider, Christian
König, Hans-Helmut
Margraf, Jürgen
Gensichen, Jochen
description This analysis aims to identify and characterize symptom trajectories in primary care patients with panic disorder with/without agoraphobia (PD/AG) who participated in a primary care team based training involving elements of cognitive behavioural therapy (CBT). Growth Mixture Modeling was used to identify different latent classes of change in patients with PD/AG (N = 176) who underwent treatment including CBT elements. We identified three patient classes with distinct similar trajectories. Class 1 (n = 58, mean age: 46.2 years ± 13.4 years, 81% women) consisted of patients with an initially high symptom burden, but symptoms declined constantly over the intervention period. Symptoms of patients in class 2 (n = 89, mean age: 44.2 years ± 14.5 years, 67.4% women) declined rapidly at the beginning, then patients went into a plateau-phase. The third class (n = 29, mean age: 47.0 years ± 12.4 years, 65.5% women) was characterized by an unstable course and had the worse outcome. Our findings show that only a minority did not respond to the treatment. To identify this minority and refer to a specialist would help patients to get intensive care in time.
doi_str_mv 10.1038/s41598-019-43487-x
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subjects 692/308
692/308/409
Adult
Age
Agoraphobia - complications
Anxiety
Cognitive ability
Cognitive Behavioral Therapy
Educational Status
Female
Humanities and Social Sciences
Humans
Male
Middle Aged
multidisciplinary
Panic attacks
Panic Disorder - complications
Panic Disorder - pathology
Panic Disorder - therapy
Primary care
Primary Health Care
Science
Science (multidisciplinary)
Treatment Outcome
title Symptom trajectories in patients with panic disorder in a primary care intervention: Results from a randomized controlled trial (PARADISE)
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