The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents
Breast cancer type 1 susceptibility protein (BRCA1) is a tumor suppressor gene that encodes a nuclear phosphoprotein, which is involved in homologous recombination to repair DNA double strand breaks and maintain genome stability. When BRCA1 is mutated or altered, DNA damage may not be effectively re...
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| Veröffentlicht in: | Oncology letters 2019-06, Vol.17 (6), p.5023-5029 |
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| creator | Kim, Geon Kim, Jisu Han, Su-Young Hwang, In Gyu Kim, Hee Sung Min, Hyeyoung |
| description | Breast cancer type 1 susceptibility protein (BRCA1) is a tumor suppressor gene that encodes a nuclear phosphoprotein, which is involved in homologous recombination to repair DNA double strand breaks and maintain genome stability. When BRCA1 is mutated or altered, DNA damage may not be effectively repaired, which leads to DNA replication errors and cancer growth. Accordingly, people carrying a mutation in the BRCA1 gene possess an increased risk of several types of cancer, including breast and ovarian cancer. Previous clinical studies have reported an association between BRCA1 expression level and the incidence of gastric cancer; however, to the best of our knowledge, an
study has not been performed to support these clinical observations. Therefore, the present study evaluated BRCA1 expression levels in gastric cancer cell lines. In addition, the IC
values of cisplatin and oxaliplatin in each cell line were determined to investigate a potential correlation between BRCA1 expression level and chemosensitivity to platinum agents. The present results revealed that the BRCA1 expression level in gastric cancer is variable and associated with the treatment response to platinum-based chemotherapy. This suggests that BRCA1 may serve as a therapeutic marker for platinum-based chemotherapy in gastric cancer. |
| doi_str_mv | 10.3892/ol.2019.10169 |
| format | Article |
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study has not been performed to support these clinical observations. Therefore, the present study evaluated BRCA1 expression levels in gastric cancer cell lines. In addition, the IC
values of cisplatin and oxaliplatin in each cell line were determined to investigate a potential correlation between BRCA1 expression level and chemosensitivity to platinum agents. The present results revealed that the BRCA1 expression level in gastric cancer is variable and associated with the treatment response to platinum-based chemotherapy. This suggests that BRCA1 may serve as a therapeutic marker for platinum-based chemotherapy in gastric cancer.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2019.10169</identifier><identifier>PMID: 31186713</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Analysis ; Biotechnology ; Breast cancer ; Cancer ; Cancer cells ; Cancer genetics ; Cancer research ; Cancer treatment ; Care and treatment ; Chemotherapy ; Clinical trials ; Disease susceptibility ; DNA ; DNA damage ; DNA replication ; Gastric cancer ; Gene expression ; Genes ; Genetic aspects ; Genetic susceptibility ; Genomes ; Genomics ; Kinases ; Medical research ; Mutation ; Ovarian cancer ; Stomach cancer ; Studies ; Tumors</subject><ispartof>Oncology letters, 2019-06, Vol.17 (6), p.5023-5029</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Kim et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c430t-71dd1288ccfb564a10186aab481d3b78ff1dba9375b3e4178e4fd9d3a30c5e133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507359/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507359/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31186713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Geon</creatorcontrib><creatorcontrib>Kim, Jisu</creatorcontrib><creatorcontrib>Han, Su-Young</creatorcontrib><creatorcontrib>Hwang, In Gyu</creatorcontrib><creatorcontrib>Kim, Hee Sung</creatorcontrib><creatorcontrib>Min, Hyeyoung</creatorcontrib><title>The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Breast cancer type 1 susceptibility protein (BRCA1) is a tumor suppressor gene that encodes a nuclear phosphoprotein, which is involved in homologous recombination to repair DNA double strand breaks and maintain genome stability. When BRCA1 is mutated or altered, DNA damage may not be effectively repaired, which leads to DNA replication errors and cancer growth. Accordingly, people carrying a mutation in the BRCA1 gene possess an increased risk of several types of cancer, including breast and ovarian cancer. Previous clinical studies have reported an association between BRCA1 expression level and the incidence of gastric cancer; however, to the best of our knowledge, an
study has not been performed to support these clinical observations. Therefore, the present study evaluated BRCA1 expression levels in gastric cancer cell lines. In addition, the IC
values of cisplatin and oxaliplatin in each cell line were determined to investigate a potential correlation between BRCA1 expression level and chemosensitivity to platinum agents. The present results revealed that the BRCA1 expression level in gastric cancer is variable and associated with the treatment response to platinum-based chemotherapy. This suggests that BRCA1 may serve as a therapeutic marker for platinum-based chemotherapy in gastric cancer.</description><subject>Analysis</subject><subject>Biotechnology</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer cells</subject><subject>Cancer genetics</subject><subject>Cancer research</subject><subject>Cancer treatment</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Disease susceptibility</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA replication</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic susceptibility</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Kinases</subject><subject>Medical research</subject><subject>Mutation</subject><subject>Ovarian cancer</subject><subject>Stomach cancer</subject><subject>Studies</subject><subject>Tumors</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkt9rFDEQx4Motpx99FUCgviyZ2azP7Ivwnn4CwqC1OeQzU5uU7KbM8kW-9-btfVsHQIJ5MN35jszhLwEtuWiK995ty0ZdFtg0HRPyDm0XVkAE-XT07utzshFjNcsR92AEM1zcsYBRNMCPyf91YgUjUGdIvWGfvi-3wHFX8eAMVo_03xSRvSIk484R5vsjU23K3tQMQWrqVazxkA1Ohdp8vToVLLzMlF1wDnFF-SZUS7ixf29IT8-fbzafykuv33-ut9dFrriLBUtDAOUQmht-rqpVPYkGqX6SsDA-1YYA0OvOt7WPccKWoGVGbqBK850jcD5hry_0z0u_YSDzrmDcvIY7KTCrfTKysc_sx3lwd_IpmYtr7ss8PZeIPifC8YkJxtXV2pGv0RZ8oqxXCvUGX39H3rtlzBne7LMUVVQ8vYfdVAOpZ2Nz3n1Kip3tWgA6i4PYUPePKBGVC6N0bsl5fbHx2BxB-rgYwxoTt6AyXUfpHdy3Qf5Zx8y_-phQ0703-nz39hEr0k</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Kim, Geon</creator><creator>Kim, Jisu</creator><creator>Han, Su-Young</creator><creator>Hwang, In Gyu</creator><creator>Kim, Hee Sung</creator><creator>Min, Hyeyoung</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190601</creationdate><title>The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents</title><author>Kim, Geon ; Kim, Jisu ; Han, Su-Young ; Hwang, In Gyu ; Kim, Hee Sung ; Min, Hyeyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-71dd1288ccfb564a10186aab481d3b78ff1dba9375b3e4178e4fd9d3a30c5e133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Biotechnology</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer cells</topic><topic>Cancer genetics</topic><topic>Cancer research</topic><topic>Cancer treatment</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Disease susceptibility</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA replication</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic susceptibility</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Kinases</topic><topic>Medical research</topic><topic>Mutation</topic><topic>Ovarian cancer</topic><topic>Stomach cancer</topic><topic>Studies</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Kim, Geon</creatorcontrib><creatorcontrib>Kim, Jisu</creatorcontrib><creatorcontrib>Han, Su-Young</creatorcontrib><creatorcontrib>Hwang, In Gyu</creatorcontrib><creatorcontrib>Kim, Hee Sung</creatorcontrib><creatorcontrib>Min, Hyeyoung</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Geon</au><au>Kim, Jisu</au><au>Han, Su-Young</au><au>Hwang, In Gyu</au><au>Kim, Hee Sung</au><au>Min, Hyeyoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>17</volume><issue>6</issue><spage>5023</spage><epage>5029</epage><pages>5023-5029</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Breast cancer type 1 susceptibility protein (BRCA1) is a tumor suppressor gene that encodes a nuclear phosphoprotein, which is involved in homologous recombination to repair DNA double strand breaks and maintain genome stability. 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study has not been performed to support these clinical observations. Therefore, the present study evaluated BRCA1 expression levels in gastric cancer cell lines. In addition, the IC
values of cisplatin and oxaliplatin in each cell line were determined to investigate a potential correlation between BRCA1 expression level and chemosensitivity to platinum agents. The present results revealed that the BRCA1 expression level in gastric cancer is variable and associated with the treatment response to platinum-based chemotherapy. This suggests that BRCA1 may serve as a therapeutic marker for platinum-based chemotherapy in gastric cancer.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>31186713</pmid><doi>10.3892/ol.2019.10169</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Analysis Biotechnology Breast cancer Cancer Cancer cells Cancer genetics Cancer research Cancer treatment Care and treatment Chemotherapy Clinical trials Disease susceptibility DNA DNA damage DNA replication Gastric cancer Gene expression Genes Genetic aspects Genetic susceptibility Genomes Genomics Kinases Medical research Mutation Ovarian cancer Stomach cancer Studies Tumors |
| title | The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents |
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