Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa

Melimine and Mel4 are chimeric cationic peptides with broad-spectrum antimicrobial activity. They have been shown to be highly biocompatible in animal models and human clinical trials. The current study examined the mechanism of action of these two antimicrobial peptides against P. aeruginosa . The...

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Veröffentlicht in:	Scientific reports 2019-05, Vol.9 (1), p.7063, Article 7063
Hauptverfasser:	Yasir, Muhammad, Dutta, Debarun, Willcox, Mark D. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/34 631/326 692/699 96 96/31 Adenosine Triphosphate - metabolism Animal models Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antimicrobial activity Antimicrobial agents Antimicrobial Cationic Peptides - metabolism Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides ATP Bactericidal activity Cationic peptides Cell Membrane - drug effects Cell Membrane Permeability - drug effects Cell Polarity - drug effects Cell viability Clinical trials Cytoplasmic membranes Deoxyribonucleic acid DNA DNA, Bacterial - metabolism Endotoxins Flow cytometry Humanities and Social Sciences Lipid A Lipid A - metabolism Lysis Membranes Microbial Sensitivity Tests Mode of action multidisciplinary Neutralization Peptides Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Ribonucleic acid RNA RNA, Bacterial - metabolism Science Science (multidisciplinary)
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