Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor-Positive Metastatic Breast Cancer

A large-panel gene expression analysis was conducted to identify biomarkers associated with the effectiveness of adding palbociclib to fulvestrant. The PALOMA-3 ( ClinicalTrials.gov identifier: NCT01942135) trial randomly assigned 521 endocrine-pretreated patients with metastatic breast cancer to re...

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Veröffentlicht in:	Journal of clinical oncology 2019-05, Vol.37 (14), p.1169-1178
Hauptverfasser:	Turner, Nicholas C, Liu, Yuan, Zhu, Zhou, Loi, Sherene, Colleoni, Marco, Loibl, Sibylle, DeMichele, Angela, Harbeck, Nadia, André, Fabrice, Bayar, Mohamed Amine, Michiels, Stefan, Zhang, Zhe, Giorgetti, Carla, Arnedos, Monica, Huang Bartlett, Cynthia, Cristofanilli, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - genetics Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cyclin E - biosynthesis Cyclin E - genetics Female Fulvestrant - administration & dosage Fulvestrant - therapeutic use Gene Expression Profiling Humans Neoplasm Metastasis Oncogene Proteins - biosynthesis Oncogene Proteins - genetics ORIGINAL REPORTS Piperazines - administration & dosage Progression-Free Survival Proportional Hazards Models Pyridines - administration & dosage Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics
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