A Compendium of Mutational Signatures of Environmental Agents

Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed to 79 known or suspected environmental carcinogens. Forty-one yielded characte...

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Veröffentlicht in:	Cell 2019-05, Vol.177 (4), p.821-836.e16
Hauptverfasser:	Kucab, Jill E., Zou, Xueqing, Morganella, Sandro, Joel, Madeleine, Nanda, A. Scott, Nagy, Eszter, Gomez, Celine, Degasperi, Andrea, Harris, Rebecca, Jackson, Stephen P., Arlt, Volker M., Phillips, David H., Nik-Zainal, Serena
Format:	Artikel
Sprache:	eng
Schlagworte:	carcinogens Carcinogens, Environmental - adverse effects Carcinogens, Environmental - classification DNA DNA damage DNA Damage - genetics DNA Mutational Analysis - methods DNA Repair - genetics DNA Replication environmental mutagens etiology Genetic Profile genome Genome, Human - genetics Humans INDEL Mutation - genetics Mutagenesis mutagens mutation Mutation - genetics Mutational signatures neoplasms Neoplasms - genetics Pluripotent Stem Cells - metabolism stem cells topography Whole Genome Sequencing - methods
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