The Epigenetic Factor CBP Is Required for the Differentiation and Function of Medial Ganglionic Eminence-Derived Interneurons

The development of inhibitory circuits depends on the action of a network of transcription factors and epigenetic regulators that are critical for interneuron specification and differentiation. Although the identity of many of these transcription factors is well established, much less is known about...

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Veröffentlicht in:	Molecular neurobiology 2019-06, Vol.56 (6), p.4440-4454
Hauptverfasser:	Medrano-Fernández, Alejandro, Delgado-Garcia, Jose M., del Blanco, Beatriz, Llinares, Marián, Sánchez-Campusano, Raudel, Olivares, Román, Gruart, Agnès, Barco, Angel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferase Action Potentials Animals Anxiety Anxiety - complications Anxiety - physiopathology Behavior, Animal Biomedical and Life Sciences Biomedicine Cell Biology Cell Differentiation - genetics Chromatin Chromosome Mapping Cognition Disorders - complications Cognition Disorders - physiopathology Cognitive ability Epigenesis, Genetic Epigenetics Epilepsy Epilepsy - complications Epilepsy - pathology Epilepsy - physiopathology Fate maps Female Forebrain Gene mapping Hippocampus - metabolism Interneurons Interneurons - cytology Interneurons - metabolism Kainic Acid Learning Lysine Male Median Eminence - cytology Membrane Proteins - metabolism Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neural stem cells Neurobiology Neurology Neurosciences Parvalbumins - metabolism Phosphoproteins - metabolism Recombination Seizures Somatostatin - metabolism Thyroid Nuclear Factor 1 - metabolism Transcription factors
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